Origin of the third heart sound: Comparison of ventricular wall dynamics in hyperdynamic and hypodynamic types

• Published in: Journal of the American College of Cardiology 1985-02, Vol.5 (2), p.268-272
• Main Authors: Ishimitsu, Toshiyuki, Smith, Damon, Berko, Barbara, Craige, Ernest
• Format: Article
• Language: English
• Subjects: Acute Disease; Animals; Biological and medical sciences; Cardiovascular system; Dogs; Echocardiography; Electrophysiology; Heart - physiopathology; Heart Auscultation; Heart Sounds; Hemodynamics; Hypoxia - physiopathology; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Mitral Valve Insufficiency - physiopathology; Stroke Volume
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/S0735-1097(85)80046-2

To investigate the left ventricular wall dynamics conducive to the third heart sound (S3) in both hyper- and hypodynamic filling conditions, eight dogs were studied in which an S3was produced by hypoxemia and in eight others by acute mitral regurgitation. Pulse transit sonomicrometry crystals were used to measure external left ventricular dimension dynamics in the two principal axes. A miniature accelerometer was used to detect the epicardial S3vibration. The development of the S3was invariably associated with an increased peak velocity of long-axis external dimensional expansion in early diastole. This enhanced long-axis filling activity was not dependent on increased global chamber or short-axis filling dynamics and sometimes occurred when global filling rate was unchanged. In addition, the short-axis filling rate was sometimes reduced as the S3developed. It is concluded that the common denominator of S3generation in this acute dog model is exaggerated longaxis diastolic expansion activity which is present in both hyper- and hypodynamic left ventricular filling.