Enhancement of natural killer cell activity and 2‐5A synthetase in operable breast cancer patients treated with polyadenylic; polyuridylic acid

Treatment of operable breast cancer patients with a single injection of 60 mg poly(A); poly(U) (polyadenylic, polyuridylic acid) resulted in an enhancement of natural killer (NK) cell cytotoxicity against human myeloid K562 target cells. Furthermore, the level of 2–5A synthetase in peripheral blood...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1985-01, Vol.55 (2), p.357-362
Main Authors: Hovanessian, Ara G., Youn, Jung Koo, Buffet‐Janvresse, Claudine, Riviere, Yves, Michelson, Michael, Lacour, Jean, Lacour, Fanny
Format: Article
Language:English
Subjects:
2',5'-Oligoadenylate Synthetase - blood
Adult
Aged
Antibody-Dependent Cell Cytotoxicity
Antineoplastic agents
Biological and medical sciences
Breast Neoplasms - drug therapy
Breast Neoplasms - immunology
Breast Neoplasms - surgery
Cells, Cultured
Chemotherapy
Female
Humans
Interferons - blood
Killer Cells, Natural - immunology
Lymphocytes - enzymology
Mastectomy
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Poly A-U - therapeutic use
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Treatment of operable breast cancer patients with a single injection of 60 mg poly(A); poly(U) (polyadenylic, polyuridylic acid) resulted in an enhancement of natural killer (NK) cell cytotoxicity against human myeloid K562 target cells. Furthermore, the level of 2–5A synthetase in peripheral blood lymphocytes of such patients was increased after the treatment. Both of these effects, measured 24 and 48 hours after the injection of poly(A); poly(U), were statistically significant compared to their respective levels before the treatment. These events, therefore, may be used as markers to monitor the immediate response of patients toward treatment with this synthetic double‐stranded RNA.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19850115)55:2<357::AID-CNCR2820550210>3.0.CO;2-5