Assessing Differential Drug Effect

The regression effect gives a misleading impression of the relationship between drug or treatment effect and baseline measurement. We propose a method of adjusting for the regression effect; we also suggest a corresponding test for the differential drug effect. The likelihood ratio test for no diffe...

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Bibliographic Details
Published in:Biometrics 1984-12, Vol.40 (4), p.1109-1115
Main Authors: Berry, D. A., Eaton, M. L., Ekholm, B. P., Fox, T. L.
Format: Article
Language:English
Subjects:
Additive effects
Antiarrhythmics
Biological and medical sciences
Biometrics
Biometry - methods
Blood pressure
Clinical Trials as Topic
Diastolic blood pressure
Drug effects
Drug Therapy
General pharmacology
Humans
Medical sciences
Percentage change
Pharmacology. Drug treatments
Ratio test
Regression Analysis
Shorter Communications
Statistical discrepancies
T tests
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Description
Summary:The regression effect gives a misleading impression of the relationship between drug or treatment effect and baseline measurement. We propose a method of adjusting for the regression effect; we also suggest a corresponding test for the differential drug effect. The likelihood ratio test for no differential drug effect is equivalent to a test for equality of variances, suggested by Pitman (1939, Biometrika 31, 9-12) and Morgan (1939, Biometrika 31, 13-19). The proposed adjustment and test are applied to an example of blood pressure data.
ISSN:0006-341X
1541-0420
DOI:10.2307/2531162