Oral and Extraoral Plasmablastic Lymphoma: Similarities and Differences in Clinicopathologic Characteristics

Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We revi...

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Bibliographic Details
Published in:American journal of clinical pathology 2010-11, Vol.134 (5), p.710-719
Main Authors: HANSRA, Damien, MONTAGUE, Naomi, STEFANOVIC, Alexandra, AKUNYILI, Ikechukwu, HARZAND, Arash, NATKUNAM, Yasodha, DE LA OSSA, Margarita, BYRNE, Gerald E, LOSSOS, Izidore S
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Child, Preschool
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - pathology
HIV Infections - complications
HIV Infections - pathology
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunohistochemistry
Immunopathology
In Situ Hybridization
Infectious diseases
Investigative techniques, diagnostic techniques (general aspects)
Kaplan-Meier Estimate
Lymphoma, Large B-Cell, Diffuse - complications
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Large-Cell, Immunoblastic - complications
Lymphoma, Large-Cell, Immunoblastic - pathology
Male
Medical sciences
Middle Aged
Mouth Mucosa - pathology
Mouth Neoplasms - complications
Mouth Neoplasms - pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Plasma Cells - pathology
Retrospective Studies
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Description
Summary:Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non-HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPJH6KEUSECQLU