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Syntheses and complement inhibitory activities of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids

The syntheses of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids are described. These compounds express potent in vitro inhibition of the human classical complement pathway, and qualitative SAR have been determined. Several of the in vitro active compounds also suppressed the complement dep...

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Published in:	Journal of medicinal chemistry 1985-02, Vol.28 (2), p.160-164
Main Authors:	Bailey, Denis M, DeGrazia, George D, Alexander, E. John, Powles, Ronald G, Johnson, Robert E, Patrick, Richard A, Heerdt, Barbara G, Fairbain, Margo E, Pruden, Donald J
Format:	Article
Language:	English
Subjects:	Animals Arthus Reaction Chemistry Complement Inactivator Proteins - chemical synthesis Complement Pathway, Classical - drug effects Cyclohexanecarboxylic Acids - chemical synthesis Cyclohexanecarboxylic Acids - pharmacology Exact sciences and technology Guinea Pigs Hemolysis Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Humans Male Organic chemistry Preparations and properties Stereoisomerism
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container_end_page	164
container_issue	2
container_start_page	160
container_title	Journal of medicinal chemistry
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creator	Bailey, Denis M DeGrazia, George D Alexander, E. John Powles, Ronald G Johnson, Robert E Patrick, Richard A Heerdt, Barbara G Fairbain, Margo E Pruden, Donald J
description	The syntheses of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids are described. These compounds express potent in vitro inhibition of the human classical complement pathway, and qualitative SAR have been determined. Several of the in vitro active compounds also suppressed the complement dependent reverse passive Arthus reaction (RPAR) in guinea pigs.
doi_str_mv	10.1021/jm00380a002
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subjects	Animals Arthus Reaction Chemistry Complement Inactivator Proteins - chemical synthesis Complement Pathway, Classical - drug effects Cyclohexanecarboxylic Acids - chemical synthesis Cyclohexanecarboxylic Acids - pharmacology Exact sciences and technology Guinea Pigs Hemolysis Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Humans Male Organic chemistry Preparations and properties Stereoisomerism
title	Syntheses and complement inhibitory activities of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids
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