Ciprofloxacin as Therapy for Experimental Osteomyelitis Caused by Pseudomonas aeruginosa

Ciprofloxacin, a new carboxyquinoline antimicrobial agent, was compared with tobramycin in the treatment of chronic osteomyelitis due to Pseudomonas aeruginosa in rabbits. Treatment with tobramycin for four weeks was ineffective (94% had positive bone cultures). In contrast, ciprofloxacin administer...

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Bibliographic Details
Published in:The Journal of infectious diseases 1985-02, Vol.151 (2), p.291-294
Main Authors: Norden, Carl W., Shinners, Ellen
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobials
Biological and medical sciences
Body weight
Bone and Bones - analysis
Bones
Chronic Disease
Ciprofloxacin
Drug Resistance, Microbial
Injections
Inoculum
Medical sciences
Medical treatment
Original Articles
Osteomyelitis
Osteomyelitis - drug therapy
Osteomyelitis - etiology
Osteomyelitis - microbiology
Pharmacology. Drug treatments
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
Quinolines - analysis
Quinolines - blood
Quinolines - pharmacology
Quinolines - therapeutic use
Rabbits
Sterilization
Tobramycin - therapeutic use
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Description
Summary:Ciprofloxacin, a new carboxyquinoline antimicrobial agent, was compared with tobramycin in the treatment of chronic osteomyelitis due to Pseudomonas aeruginosa in rabbits. Treatment with tobramycin for four weeks was ineffective (94% had positive bone cultures). In contrast, ciprofloxacin administered for four weeks sterilized the bones of all but one (94%) of 18 treated rabbits. Treatment with ciprofloxacin for two weeks was less effective than treatment for four weeks but was more effective than either treatment with tobramycin or no therapy. Two of 10 isolates from rabbits treated with ciprofloxacin for two weeks were susceptible to MICs of ciprofloxacin that were 16- and fourfold greater than the MIC for the parent strain; the other eight isolates remained sensitive to ciprofloxacin with MICs equivalent to that of the parent strain.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/151.2.291