Haemoglobin F and A2 in Nigerian children with sickle cell anaemia

The concentration of haemoglobins F and A2 in 132 Hb SS children aged 6 months to 16 years and 50 age- and sex-matched controls has been determined. The mean HbF concentration in Hb SS patients and controls were 9.5 per cent (range 1.7-24.5 per cent) and 1.5 per cent (range 0.5-14.4 per cent) respec...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1993-08, Vol.39 (4), p.251-252
Main Authors: FATUNDE, O. J, SCOTT-EMUAKPOR, A. B
Format: Article
Language:English
Subjects:
Adolescent
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - diagnosis
Anemias. Hemoglobinopathies
Biological and medical sciences
Child
Child, Preschool
Diseases of red blood cells
Female
Fetal Hemoglobin - physiology
Hematologic and hematopoietic diseases
Hemoglobin A2 - physiology
Humans
Infant
Male
Medical sciences
Nigeria
Tropical medicine
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Summary:The concentration of haemoglobins F and A2 in 132 Hb SS children aged 6 months to 16 years and 50 age- and sex-matched controls has been determined. The mean HbF concentration in Hb SS patients and controls were 9.5 per cent (range 1.7-24.5 per cent) and 1.5 per cent (range 0.5-14.4 per cent) respectively while HbA2 concentrations were 2.7 per cent (range 1.6-3.7 per cent) and 2.4 per cent (range 1.3-3.9 per cent) respectively. For 18 Hb SS patients seen in the stable state and during vaso-occlusive crisis, there was no significant difference in HbF concentration between the two states.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/39.4.251