Comparison of the cellular pharmacology of doxorubicin in resistant and sensitive models of pancreatic cancer

The cellular accumulation and retention of doxorubicin (ADR) was investigated in two models of pancreatic adenocarcinoma, which differ markedly in their sensitivity to ADR. In vitro studies revealed that the relatively resistant cell line, WD PaCa (or well-differentiated pancreatic adenocarcinoma of...

Full description

Saved in:
Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1985-01, Vol.14 (2), p.132-134
Main Authors: CHANG, B. K, GREGORY, J. A
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Animals
Antineoplastic agents
Biological and medical sciences
Cell Count
Cell Line
Cell Survival - drug effects
Doxorubicin - metabolism
Drug Resistance
General aspects
Medical sciences
Models, Biological
Pancreatic Neoplasms - metabolism
Pharmacology. Drug treatments
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cellular accumulation and retention of doxorubicin (ADR) was investigated in two models of pancreatic adenocarcinoma, which differ markedly in their sensitivity to ADR. In vitro studies revealed that the relatively resistant cell line, WD PaCa (or well-differentiated pancreatic adenocarcinoma of the Syrian hamster), actually had higher ADR cellular levels than the sensitive cell line, PD PaCa (or poorly differentiated pancreatic adenocarcinoma of the Syrian hamster). While the efflux of ADR from WD PaCa was greater, the overall retention of ADR by WD PaCa was comparable to PD PaCa. These results failed to document differences in accumulation or retention of ADR capable of explaining the difference in the sensitivity of the cell lines to ADR and indicate the need to search beyond attainable drug concentrations for mechanisms of primary ADR resistance.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00434351