Age-related changes in venous catecholamines basally and during epinephrine infusion in man

Plasma epinephrine (EPI) and norepinephrine (NE) levels were examined among healthy men aged 20 to 25 and 60 to 65 years basally and during EPI infusions. On separate days, 14.3 and 42.9 ng/kg/min EPI was administered intravenously for 45 min. Although there was no age difference in venous EPI level...

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Bibliographic Details
Published in:Journal of gerontology (Kirkwood) 1985-03, Vol.40 (2), p.133-140
Main Authors: Wilkie, F L, Halter, J B, Prinz, P N, Benedetti, C, Eisdorfer, C, Atwood, B, Yamasaki, D
Format: Article
Language:English
Subjects:
Adult
Aged
Aging
Blood Pressure - drug effects
Epinephrine - administration & dosage
Epinephrine - blood
Epinephrine - pharmacology
Heart Rate - drug effects
Humans
Infusions, Parenteral
Male
Metabolic Clearance Rate
Middle Aged
Norepinephrine - blood
Sex Factors
Veins
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Summary:Plasma epinephrine (EPI) and norepinephrine (NE) levels were examined among healthy men aged 20 to 25 and 60 to 65 years basally and during EPI infusions. On separate days, 14.3 and 42.9 ng/kg/min EPI was administered intravenously for 45 min. Although there was no age difference in venous EPI levels basally, the old had less increase during the EPI infusions. The plasma metabolic clearance rate of EPI was greater among the old men. Plasma NE levels were elevated among the elderly men, but both age groups had an increase in NE during the EPI 42.9 ng/kg/min infusion rate. During EPI infusions, the old men had less increase in systolic but not diastolic blood pressure or heart rate compared with the young men. The different pattern of change in venous EPI levels and increased metabolic clearance rate of EPI observed among the old men could, in part, explain diminished end-organ responsivity.
ISSN:0022-1422
2331-3323
DOI:10.1093/geronj/40.2.133