Bortezomib: a new player in pre- and post-transplant desensitization?

Several desensitization strategies have been investigated for the reversal of acute antibody-mediated rejection or for the removal of preformed anti-HLA antibodies, with the aim to promote access to renal transplantation. Today, their success appears limited or incomplete. Bortezomib, a selective in...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2010-11, Vol.25 (11), p.3480-3489
Main Authors: Lemy, Anne, Toungouz, Michel, Abramowicz, Daniel
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Boronic Acids - pharmacology
Boronic Acids - therapeutic use
Bortezomib
Dendritic Cells - drug effects
desensitization
Desensitization, Immunologic - methods
donor-specific antibodies
Emergency and intensive care: renal failure. Dialysis management
Graft Rejection - prevention & control
HLA Antigens - immunology
Humans
Intensive care medicine
Isoantibodies - blood
Kidney Transplantation - immunology
Medical sciences
NF-kappa B - antagonists & inhibitors
NF-kappa B - physiology
Pyrazines - pharmacology
Pyrazines - therapeutic use
rejection
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
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Description
Summary:Several desensitization strategies have been investigated for the reversal of acute antibody-mediated rejection or for the removal of preformed anti-HLA antibodies, with the aim to promote access to renal transplantation. Today, their success appears limited or incomplete. Bortezomib, a selective inhibitor of the 26S proteasome, which is largely used in the treatment of multiple myeloma, could be a novel promising desensitizing agent. Its mechanism of action and preliminary clinical use in renal transplantation is reviewed here.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfq502