Tomographic molecular imaging of x-ray-excitable nanoparticles

X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality. XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. As a proof of concept, we built a prototype XLCT system and imaged near-IR-emitting Gd(2)O(...

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Bibliographic Details
Published in:Optics letters 2010-10, Vol.35 (20), p.3345-3347
Main Authors: PRATX, Guillem, CARPENTER, Colin M, SUN, Conroy, RAO, Ravi P, LEI XING
Format: Article
Language:English
Subjects:
Europium - chemistry
Exact sciences and technology
Fundamental areas of phenomenology (including applications)
Gadolinium - chemistry
Image Processing, Computer-Assisted - methods
Image reconstruction
tomography
Imaging and optical processing
Luminescent Measurements - instrumentation
Nanoparticles - chemistry
Optics
Phantoms, Imaging
Physics
Tomography Scanners, X-Ray Computed
Tomography, X-Ray Computed - instrumentation
X-Rays
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Description
Summary:X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality. XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. As a proof of concept, we built a prototype XLCT system and imaged near-IR-emitting Gd(2)O(2)S:Eu phosphors in various phantoms. Imaging in an optically diffusive medium shows that imaging performance is not affected by optical scatter; furthermore, the linear response of the reconstructed images suggests that XLCT is capable of quantitative imaging.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.35.003345