Assessment of bone marrow involvement in non-Hodgkin's lymphomas: comparison between histology and flow cytometry

Bone marrow (BM) examination is essential in the staging of non‐Hodgkin’s lymphoma (NHL) patients. Few studies have compared BM histologic findings with results of flow cytometric (FC) analysis. We analyzed the incidence and patterns of histologic BM involvement in a series of 753 patients with NHL....

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Bibliographic Details
Published in:European journal of haematology 2010-11, Vol.85 (5), p.405-415
Main Authors: Merli, Michele, Arcaini, Luca, Boveri, Emanuela, Rattotti, Sara, Picone, Cristina, Passamonti, Francesco, Tenore, Annamaria, Sozzani, Laura, Lucioni, Marco, Varettoni, Marzia, Rizzi, Silvia, Morello, Lucia, Ferretti, Virginia, Pascutto, Cristiana, Paulli, Marco, Lazzarino, Mario
Format: Article
Language:English
Subjects:
Bone Marrow - pathology
Bone Marrow Examination - methods
bone marrow histology
Flow Cytometry
Histological Techniques
Humans
Lymphoma, Follicular
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Non-Hodgkin - pathology
non-Hodgkin's lymphoma
Retrospective Studies
staging
Waldenstrom Macroglobulinemia
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Summary:Bone marrow (BM) examination is essential in the staging of non‐Hodgkin’s lymphoma (NHL) patients. Few studies have compared BM histologic findings with results of flow cytometric (FC) analysis. We analyzed the incidence and patterns of histologic BM involvement in a series of 753 patients with NHL. For 498 patients, a concurrent FC analysis on BM was available. Histologic involvement was detected at diagnosis in 311/753 (41%) patients. By FC, BM involvement was clearly detected in 150/498 (30%). After excluding 12 cases with equivocal histology, concordance between the two methods was detected in 411 (85%) cases (27% BMB+/FC+; 58% BMB−/FC−), while discordance was present in 75 (15%) (P 
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.2010.01503.x