DFMO Reduces Cortical Infarct Volume After Middle Cerebral Artery Occlusion in the Rat

Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is induced in ischemic tissue and may mediate vasogenic edema and delayed neuronal death. We determined the effects of α-difluoromethylornithine (DFMO), a specific inhibitor of ODC, on infarct size and ODC activity in a rat model...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1993-11, Vol.13 (6), p.1033-1037
Main Authors: Muszynski, Cheryl A., Robertson, Claudia S., Goodman, J. Clay, Henley, Charles M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cerebral Arteries
Cerebral Infarction - etiology
Cerebral Infarction - pathology
Cerebral Infarction - prevention & control
Constriction
Eflornithine - therapeutic use
Ischemic Attack, Transient - complications
Male
Medical sciences
Neuropharmacology
Neuroprotective agent
Ornithine Decarboxylase - metabolism
Ornithine Decarboxylase Inhibitors
Parietal Lobe - enzymology
Parietal Lobe - pathology
Pharmacology. Drug treatments
Rats
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Summary:Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is induced in ischemic tissue and may mediate vasogenic edema and delayed neuronal death. We determined the effects of α-difluoromethylornithine (DFMO), a specific inhibitor of ODC, on infarct size and ODC activity in a rat model of transient focal ischemia. DFMO blocked the ischemia-induced increase in ODC and significantly reduced infarct volumes by 57–45%, depending upon the treatment regimen. These studies suggest that polyamine metabolism plays a role in the development of cerebral infarction after focal ischemia and that DFMO may be useful in limiting injury after a stroke.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1993.131