Potassium regulates plasma testosterone and renal ornithine decarboxylase in mice

Potassium deficiency produced different effects in the kidney of male or female mice. While in female, potassium deficiency caused a marked renal hypertrophy with no significant changes in testosterone-regulated enzymes, such as ornithine decarboxylase and β-glucuronidase, in the male the same treat...

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Bibliographic Details
Published in:FEBS letters 1993-10, Vol.333 (1), p.32-34
Main Authors: Sánchez-Capelo, Amelia, Cremades, Asunción, Tejada, Francisco, Fuentes, Teodomiro, Peñafiel, Rafael
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Body Weight
Enzymes and enzyme inhibitors
Female
Fundamental and applied biological sciences. Psychology
Kidney - anatomy & histology
Kidney - enzymology
Lyases
Male
Mice
Mouse kidney
Organ Size
Ornithine decarboxylase
Ornithine Decarboxylase - metabolism
Potassium
Potassium - blood
Potassium - physiology
Potassium Deficiency - metabolism
Sexual dimorphism
Testosterone
Testosterone - blood
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Summary:Potassium deficiency produced different effects in the kidney of male or female mice. While in female, potassium deficiency caused a marked renal hypertrophy with no significant changes in testosterone-regulated enzymes, such as ornithine decarboxylase and β-glucuronidase, in the male the same treatment provoked a marked fall of these enzymes owing to a dramatic decrease in plasma testosterone. Potassium replenishment restored plasma testosterone and renal enzymatic activities. These results show for the first time, that potassium modulates circulating testosterone and suggest that this cation could exert an important regulatory role in controlling androgen actions.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(93)80369-6