Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver

The effect of vitamin B6 deficiency on the activity of RNA polymerase and expression of several mRNAs in rat liver was investigated. The activities of RNA polymerase I and II in the liver of vitamin B6‐deficient rats were found to be higher than the control rats by 30%. The expression of several mRN...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 1993-09, Vol.331 (1-2), p.162-164
Main Authors: Oka, Tatsuzo, Komori, Naomi, Kuwahata, Masashi, Sassa, Toshihiro, Suzuki, Isao, Okada, Mitsuko, Natori, Yasuo
Format: Article
Language:English
Subjects:
Actins - genetics
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Coenzymes, vitamins
DNA-Directed RNA Polymerases - metabolism
Enzyme Activation
Fundamental and applied biological sciences. Psychology
Gene Expression
Glyceraldehyde-3-Phosphate Dehydrogenases - genetics
Liver - enzymology
Liver - metabolism
Male
Other biological molecules
Rat liver
Rats
Rats, Wistar
RNA polymerase
RNA, Messenger - metabolism
Vitamin B 6 Deficiency - enzymology
Vitamin B 6 Deficiency - genetics
Vitamin B6
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of vitamin B6 deficiency on the activity of RNA polymerase and expression of several mRNAs in rat liver was investigated. The activities of RNA polymerase I and II in the liver of vitamin B6‐deficient rats were found to be higher than the control rats by 30%. The expression of several mRNAs, including mRNAs for β‐actin and glyceraldehyde‐3‐phosphate dehydrogenase, and the content of poly(A)+ RNA were also increased in vitamin deficiency. These observations suggest that vitamin B6 influences gene expression in the liver, at least in part, by modulating the activity of RNA polymerase.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(93)80318-O