Familial cold urticaria

Summary Familial cold urticaria (FCU) is a rare autosomal dominant condition, first described in 1940. 1 The onset is in early life in all reported cases. Symptoms are triggered by generalized exposure to cold air, particularly in damp and windy weather. The cutaneous lesions consist of erythematous...

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Bibliographic Details
Published in:Clinical and experimental dermatology 1993-07, Vol.18 (4), p.338-341
Main Authors: ZIP, C. M., ROSS, J. B., GREAVES, M. W., SCRIVER, C. R., MITCHELL, J. J., ZOAR, S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cold Temperature - adverse effects
Family Health
Female
Humans
Injuries of the skin. Diseases of the skin due to physical agents
Medical sciences
Middle Aged
Pedigree
Traumas. Diseases due to physical agents
Urticaria - etiology
Urticaria - genetics
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Summary:Summary Familial cold urticaria (FCU) is a rare autosomal dominant condition, first described in 1940. 1 The onset is in early life in all reported cases. Symptoms are triggered by generalized exposure to cold air, particularly in damp and windy weather. The cutaneous lesions consist of erythematous macules or plaques, urticarial lesions and sometimes petechiae. Associated fever, chills, joint pains, nausea, stiffness and swelling of the hands and feet frequently occur. The symptoms are variable, ranging from mild to incapacitating. The pathogenesis of FCU remains unknown. To our knowledge only 10 pedigrees have been published, seven from the USA and one each from Holland, France and South Africa. 2‐12 We wish to report another extensive pedigree after having had the opportunity to investigate one member of the family in detail. A short form of this pedigree has been published elsewhere. 13
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.1993.tb02212.x