Insulin resistance in insulin-dependent diabetic patients with microalbuminuria

In insulin-dependent diabetes, microalbuminuria increases the risk of cardiovascular and renal disease. By means of a euglycaemic hyperinsulinaemic clamp method, we measured total-body glucose utilisation rate and studied the interaction of this measure of insulin sensitivity with known risk factors...

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Bibliographic Details
Published in:The Lancet (British edition) 1993-10, Vol.342 (8876), p.883-887
Main Authors: Yip, J., Mattock, M.B., Morocutti, A., Sethi, M., Trevisan, R., Viberti, Gc
Format: Article
Language:English
Subjects:
Adult
Albuminuria
Biological and medical sciences
Blood Glucose - analysis
Blood Pressure
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Diabetes
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 1 - physiopathology
Diabetic Nephropathies - etiology
Excretion
Female
Glucose Clamp Technique
Health risks
Hormones. Endocrine system
Humans
Insulin
Insulin - blood
Insulin Resistance
Lipids - blood
Male
Medical research
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Risk Factors
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Summary:In insulin-dependent diabetes, microalbuminuria increases the risk of cardiovascular and renal disease. By means of a euglycaemic hyperinsulinaemic clamp method, we measured total-body glucose utilisation rate and studied the interaction of this measure of insulin sensitivity with known risk factors for cardiovascular disease in 14 diabetic patients with microalbuminuria and 14 with normal albumin excretion (median albumin excretion rate [AER] 56·2 [range 39·2-80·6] vs 8·8 [7·4-10·7] μg per min). The two groups were of similar age, duration of diabetes, and body-mass index. Total-body glucose disposal rate was significantly lower in the patients with microalbuminuria than in those without (mean 7·86 [SD 1·40] vs 9·04 [0·90] mg/kg per min; p
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(93)91943-G