Intrathecal baclofen : does tolerance occur ?

Concern over the development of tolerance in patients on continuous intrathecal baclofen therapy has arisen as this new form of treatment for spasticity has gained wider use. We have studied time-dose relationships in 18 spinal cord injured patients who have undergone intrathecal baclofen infusion p...

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Bibliographic Details
Published in:Paraplegia 1993-08, Vol.31 (8), p.516-520
Main Authors: AKMAN, M. N, LOUBSER, P. G, DONOVAN, W. H, O'NEILL, M. E, ROSSI, C. D
Format: Article
Language:English
Subjects:
Baclofen - administration & dosage
Baclofen - therapeutic use
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Tolerance
Humans
Infusion Pumps, Implantable
Injections, Spinal
Medical sciences
Muscle
Muscle Spasticity - drug therapy
Muscle Spasticity - etiology
Pharmacology. Drug treatments
Spinal Cord Injuries - complications
Time Factors
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Summary:Concern over the development of tolerance in patients on continuous intrathecal baclofen therapy has arisen as this new form of treatment for spasticity has gained wider use. We have studied time-dose relationships in 18 spinal cord injured patients who have undergone intrathecal baclofen infusion pump implantation since February 1988 in our facility. Our data show that there was a significant increase in baclofen dosage needed to control spasticity during the first 12 months post implantation. After 12 months, however, no significant changes in dosage requirement was detected. In addition, there was no significant difference between completely and incompletely spinal cord injured patients with regard to both the initial dose and the tolerance trend.
ISSN:0031-1758
1362-4393
1476-5624
DOI:10.1038/sc.1993.84