Intrathecal baclofen : does tolerance occur ?

Concern over the development of tolerance in patients on continuous intrathecal baclofen therapy has arisen as this new form of treatment for spasticity has gained wider use. We have studied time-dose relationships in 18 spinal cord injured patients who have undergone intrathecal baclofen infusion p...

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Published in:Paraplegia 1993-08, Vol.31 (8), p.516-520
Main Authors: AKMAN, M. N, LOUBSER, P. G, DONOVAN, W. H, O'NEILL, M. E, ROSSI, C. D
Format: Article
Language:English
Subjects:
Baclofen - administration & dosage
Baclofen - therapeutic use
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Tolerance
Humans
Infusion Pumps, Implantable
Injections, Spinal
Medical sciences
Muscle
Muscle Spasticity - drug therapy
Muscle Spasticity - etiology
Pharmacology. Drug treatments
Spinal Cord Injuries - complications
Time Factors
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creator AKMAN, M. N
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description Concern over the development of tolerance in patients on continuous intrathecal baclofen therapy has arisen as this new form of treatment for spasticity has gained wider use. We have studied time-dose relationships in 18 spinal cord injured patients who have undergone intrathecal baclofen infusion pump implantation since February 1988 in our facility. Our data show that there was a significant increase in baclofen dosage needed to control spasticity during the first 12 months post implantation. After 12 months, however, no significant changes in dosage requirement was detected. In addition, there was no significant difference between completely and incompletely spinal cord injured patients with regard to both the initial dose and the tolerance trend.
doi_str_mv 10.1038/sc.1993.84
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identifier ISSN: 0031-1758
ispartof Paraplegia, 1993-08, Vol.31 (8), p.516-520
issn 0031-1758
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1476-5624
language eng
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source Alma/SFX Local Collection
subjects Baclofen - administration & dosage
Baclofen - therapeutic use
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Tolerance
Humans
Infusion Pumps, Implantable
Injections, Spinal
Medical sciences
Muscle
Muscle Spasticity - drug therapy
Muscle Spasticity - etiology
Pharmacology. Drug treatments
Spinal Cord Injuries - complications
Time Factors
title Intrathecal baclofen : does tolerance occur ?
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