Tc-99m Sestamibi and Other Agents in the Detection of Metastatic Medullary Carcinoma of the Thyroid

The 10-year survival rate for medullary carcinoma of the thyroid (MCT) is 50%; thus, good tumor-seeking radiopharmaceuticals are needed to localize foci of recurrence and metastasis during follow-up. Two patients with metastatic MCT were studied with Tl-201, l-131 MIBG, Tc-99m (V)-DMSA, and Tc-99m M...

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Bibliographic Details
Published in:Clinical nuclear medicine 1993-08, Vol.18 (8), p.657-660
Main Authors: LEBOUTHILLIER, GILLES, MORAIS, JACQUES, PICARD, MICHEL, PICARD, DANIEL, CHARTRAND, RAYMONDE, DʼAMOUR, PIERRE
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Medullary - diagnostic imaging
Carcinoma, Medullary - secondary
Endocrine glands. Genital system. Mammary gland
Evaluation Studies as Topic
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lymphatic Metastasis - diagnostic imaging
Male
Medical sciences
Neoplasm Recurrence, Local - diagnostic imaging
Organotechnetium Compounds
Radionuclide investigations
Succimer
Technetium Tc 99m Dimercaptosuccinic Acid
Technetium Tc 99m Sestamibi
Thyroid Neoplasms - diagnostic imaging
Tomography, Emission-Computed, Single-Photon
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Summary:The 10-year survival rate for medullary carcinoma of the thyroid (MCT) is 50%; thus, good tumor-seeking radiopharmaceuticals are needed to localize foci of recurrence and metastasis during follow-up. Two patients with metastatic MCT were studied with Tl-201, l-131 MIBG, Tc-99m (V)-DMSA, and Tc-99m MIBI. A SPECT study with the latter agent allowed the visualization and precise localization of a metastatic mediastinal lymph node. More studies need to be done to evaluate the role of Tc-99m MIBI in the detection of recurrence and metastases of MCT.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199308000-00005