Susceptibility of 126 isolates of Escherichia coli from the cerebrospinal fluid of neonates to five antibiotics

One hundred and twenty-six clinical isolates of Escherichia coli from the CSF of neonates, obtained in the Netherlands during 1976 to 1982, were tested for sensitivity to five antibiotics. The usefulness of the generally recommended initial therapy, a combination of ampicillin and gentamicin, is sup...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1985, Vol.15 (1), p.115-118
Main Authors: MULDER, C. J. J, BOL, P, NABBE, A. J. J. M, ZANEN, H. C
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cerebrospinal Fluid - microbiology
Drug Resistance, Microbial
Escherichia coli
Escherichia coli - drug effects
Humans
Infant, Newborn
Medical sciences
Meningitis - drug therapy
Meningitis - microbiology
Microbial Sensitivity Tests
Pharmacology. Drug treatments
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Summary:One hundred and twenty-six clinical isolates of Escherichia coli from the CSF of neonates, obtained in the Netherlands during 1976 to 1982, were tested for sensitivity to five antibiotics. The usefulness of the generally recommended initial therapy, a combination of ampicillin and gentamicin, is supported in the majority of cases. On the basis of the in-vitro results, cefotaxime would have been effective as a therapy for all cases. Ampicillin and cefuroxime resistance occurred mostly in neonates who had received antibiotics prophylactically, neonates whose mothers had fever during labour or in neonates who had been nursed in incubators for more than one week.
ISSN:0305-7453
1460-2091