Loading…
Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein
CLATHRIN is the structural protein of coated membranes involved in receptor-mediated endocytosis and aspects of Golgi sorting in eukaryotic cells. We have now detected a stoichiometric complex of clathrin with a novel protein of M r ~100,000 (100K) in lysates of different mammalian cells. Formation...
Saved in:
| Published in: | Nature (London) 1993-09, Vol.365 (6445), p.459-462 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c488t-e43dbb920202e38bfe8f43d828e45d4dfabe0a6b44c66463a0c6cce869497053 |
|---|---|
| cites | |
| container_end_page | 462 |
| container_issue | 6445 |
| container_start_page | 459 |
| container_title | Nature (London) |
| container_volume | 365 |
| creator | Pleasure, Irene T Black, Mark M Keen, James H |
| description | CLATHRIN is the structural protein of coated membranes involved in receptor-mediated endocytosis and aspects of Golgi sorting in eukaryotic cells. We have now detected a stoichiometric complex of clathrin with a novel protein of
M
r
~100,000 (100K) in lysates of different mammalian cells. Formation of the complex, which also includes the 70K heat-shock protein HscTO, occurs within 15 min of synthesis. The 100K protein has been identified as valosin-containing protein (VCP; ref. 1), an early substrate for tyrosine phosphorylation on T-cell receptor activation
2
. Further, VCP is the mammalian homologue of yeast Cdc48p (ref. 3) and is a member of a larger gene family that includes putative ATP-binding proteins involved in vesicle transport and fusion
4,5
, 26S proteasome function
6
, regulation of the expression of human immunodeficiency virus
7,8
, and assembly of peroxisomes
9
. The association with clathrin and the morphological and catalytic similarity to the chaperonin proteins indicate that VCP may modulate protein-protein interactions in membrane transport processes. |
| doi_str_mv | 10.1038/365459a0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76000785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4949718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-e43dbb920202e38bfe8f43d828e45d4dfabe0a6b44c66463a0c6cce869497053</originalsourceid><addsrcrecordid>eNqF0VtLwzAUAOAgypxT8A8oRUQUVj1ZkzR5lOFlMNCHsdeSpunM6NItaR_890ZWp4ggeQjkfDmXBKFTDLcYEn6XMEqokLCH-pikLCaMp_uoDzDiMfCEHaIj75cAQHFKeqjHCU6ogD6azGVVe2NjVdtGGmvsIlq7utHGDqP5-HUYGR_JqM3NpjVN3fpIVbJ5c-FGbmzxgx-jg1JWXp90-wDNHh9m4-d4-vI0Gd9PY0U4b2JNkiLPxQjC0gnPS83LcMRHXBNakKKUuQbJckIUY4QlEhRTSnMmiEiBJgN0tU0bym5a7ZtsZbzSVSWtDu1lKQtTpvx_iFl4I0pFgBe_4LJunQ0zZCMghIJIeUDXW6Rc7b3TZbZ2ZiXde4Yh-_yC7OsLAj3r8rX5Shc72L15iF92cemVrEonrTJ-x4jAOBU4sJst8yFiF9p9t_VHyfOttbJpnd7l2oEPNv2jTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204450978</pqid></control><display><type>article</type><title>Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein</title><source>Springer Nature - Connect here FIRST to enable access</source><creator>Pleasure, Irene T ; Black, Mark M ; Keen, James H</creator><creatorcontrib>Pleasure, Irene T ; Black, Mark M ; Keen, James H</creatorcontrib><description>CLATHRIN is the structural protein of coated membranes involved in receptor-mediated endocytosis and aspects of Golgi sorting in eukaryotic cells. We have now detected a stoichiometric complex of clathrin with a novel protein of
M
r
~100,000 (100K) in lysates of different mammalian cells. Formation of the complex, which also includes the 70K heat-shock protein HscTO, occurs within 15 min of synthesis. The 100K protein has been identified as valosin-containing protein (VCP; ref. 1), an early substrate for tyrosine phosphorylation on T-cell receptor activation
2
. Further, VCP is the mammalian homologue of yeast Cdc48p (ref. 3) and is a member of a larger gene family that includes putative ATP-binding proteins involved in vesicle transport and fusion
4,5
, 26S proteasome function
6
, regulation of the expression of human immunodeficiency virus
7,8
, and assembly of peroxisomes
9
. The association with clathrin and the morphological and catalytic similarity to the chaperonin proteins indicate that VCP may modulate protein-protein interactions in membrane transport processes.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/365459a0</identifier><identifier>PMID: 8413590</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3T3 Cells ; Adenosine Triphosphatases ; AIDS/HIV ; Amino Acid Sequence ; Analytical, structural and metabolic biochemistry ; Animals ; Biochemistry ; Biological and medical sciences ; Biological Transport ; Cell Cycle Proteins ; Cell Line ; Clathrin - metabolism ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - chemistry ; Heat-Shock Proteins - metabolism ; Humanities and Social Sciences ; Humans ; letter ; Mammalia ; Mammals ; Mice ; Mice, Inbred BALB C ; Miscellaneous ; Molecular Sequence Data ; multidisciplinary ; Neurons - metabolism ; Precipitin Tests ; Protein Binding ; Proteins ; Rats ; Science ; Science (multidisciplinary) ; Sympathetic Nervous System - cytology ; Sympathetic Nervous System - metabolism ; Transport processes ; Valosin Containing Protein ; Yeasts</subject><ispartof>Nature (London), 1993-09, Vol.365 (6445), p.459-462</ispartof><rights>Springer Nature Limited 1993</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Sep 30, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-e43dbb920202e38bfe8f43d828e45d4dfabe0a6b44c66463a0c6cce869497053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4911791$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8413590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pleasure, Irene T</creatorcontrib><creatorcontrib>Black, Mark M</creatorcontrib><creatorcontrib>Keen, James H</creatorcontrib><title>Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>CLATHRIN is the structural protein of coated membranes involved in receptor-mediated endocytosis and aspects of Golgi sorting in eukaryotic cells. We have now detected a stoichiometric complex of clathrin with a novel protein of
M
r
~100,000 (100K) in lysates of different mammalian cells. Formation of the complex, which also includes the 70K heat-shock protein HscTO, occurs within 15 min of synthesis. The 100K protein has been identified as valosin-containing protein (VCP; ref. 1), an early substrate for tyrosine phosphorylation on T-cell receptor activation
2
. Further, VCP is the mammalian homologue of yeast Cdc48p (ref. 3) and is a member of a larger gene family that includes putative ATP-binding proteins involved in vesicle transport and fusion
4,5
, 26S proteasome function
6
, regulation of the expression of human immunodeficiency virus
7,8
, and assembly of peroxisomes
9
. The association with clathrin and the morphological and catalytic similarity to the chaperonin proteins indicate that VCP may modulate protein-protein interactions in membrane transport processes.</description><subject>3T3 Cells</subject><subject>Adenosine Triphosphatases</subject><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Cell Cycle Proteins</subject><subject>Cell Line</subject><subject>Clathrin - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal Proteins - chemistry</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Mammalia</subject><subject>Mammals</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Neurons - metabolism</subject><subject>Precipitin Tests</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Rats</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sympathetic Nervous System - cytology</subject><subject>Sympathetic Nervous System - metabolism</subject><subject>Transport processes</subject><subject>Valosin Containing Protein</subject><subject>Yeasts</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqF0VtLwzAUAOAgypxT8A8oRUQUVj1ZkzR5lOFlMNCHsdeSpunM6NItaR_890ZWp4ggeQjkfDmXBKFTDLcYEn6XMEqokLCH-pikLCaMp_uoDzDiMfCEHaIj75cAQHFKeqjHCU6ogD6azGVVe2NjVdtGGmvsIlq7utHGDqP5-HUYGR_JqM3NpjVN3fpIVbJ5c-FGbmzxgx-jg1JWXp90-wDNHh9m4-d4-vI0Gd9PY0U4b2JNkiLPxQjC0gnPS83LcMRHXBNakKKUuQbJckIUY4QlEhRTSnMmiEiBJgN0tU0bym5a7ZtsZbzSVSWtDu1lKQtTpvx_iFl4I0pFgBe_4LJunQ0zZCMghIJIeUDXW6Rc7b3TZbZ2ZiXde4Yh-_yC7OsLAj3r8rX5Shc72L15iF92cemVrEonrTJ-x4jAOBU4sJst8yFiF9p9t_VHyfOttbJpnd7l2oEPNv2jTg</recordid><startdate>19930930</startdate><enddate>19930930</enddate><creator>Pleasure, Irene T</creator><creator>Black, Mark M</creator><creator>Keen, James H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19930930</creationdate><title>Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein</title><author>Pleasure, Irene T ; Black, Mark M ; Keen, James H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-e43dbb920202e38bfe8f43d828e45d4dfabe0a6b44c66463a0c6cce869497053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>3T3 Cells</topic><topic>Adenosine Triphosphatases</topic><topic>AIDS/HIV</topic><topic>Amino Acid Sequence</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Cell Cycle Proteins</topic><topic>Cell Line</topic><topic>Clathrin - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal Proteins - chemistry</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Mammalia</topic><topic>Mammals</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Neurons - metabolism</topic><topic>Precipitin Tests</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Rats</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sympathetic Nervous System - cytology</topic><topic>Sympathetic Nervous System - metabolism</topic><topic>Transport processes</topic><topic>Valosin Containing Protein</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pleasure, Irene T</creatorcontrib><creatorcontrib>Black, Mark M</creatorcontrib><creatorcontrib>Keen, James H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>ProQuest research library</collection><collection>Science Database (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pleasure, Irene T</au><au>Black, Mark M</au><au>Keen, James H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1993-09-30</date><risdate>1993</risdate><volume>365</volume><issue>6445</issue><spage>459</spage><epage>462</epage><pages>459-462</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>CLATHRIN is the structural protein of coated membranes involved in receptor-mediated endocytosis and aspects of Golgi sorting in eukaryotic cells. We have now detected a stoichiometric complex of clathrin with a novel protein of
M
r
~100,000 (100K) in lysates of different mammalian cells. Formation of the complex, which also includes the 70K heat-shock protein HscTO, occurs within 15 min of synthesis. The 100K protein has been identified as valosin-containing protein (VCP; ref. 1), an early substrate for tyrosine phosphorylation on T-cell receptor activation
2
. Further, VCP is the mammalian homologue of yeast Cdc48p (ref. 3) and is a member of a larger gene family that includes putative ATP-binding proteins involved in vesicle transport and fusion
4,5
, 26S proteasome function
6
, regulation of the expression of human immunodeficiency virus
7,8
, and assembly of peroxisomes
9
. The association with clathrin and the morphological and catalytic similarity to the chaperonin proteins indicate that VCP may modulate protein-protein interactions in membrane transport processes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8413590</pmid><doi>10.1038/365459a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1993-09, Vol.365 (6445), p.459-462 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76000785 |
| source | Springer Nature - Connect here FIRST to enable access |
| subjects | 3T3 Cells Adenosine Triphosphatases AIDS/HIV Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biochemistry Biological and medical sciences Biological Transport Cell Cycle Proteins Cell Line Clathrin - metabolism Fundamental and applied biological sciences. Psychology Fungal Proteins - chemistry Heat-Shock Proteins - metabolism Humanities and Social Sciences Humans letter Mammalia Mammals Mice Mice, Inbred BALB C Miscellaneous Molecular Sequence Data multidisciplinary Neurons - metabolism Precipitin Tests Protein Binding Proteins Rats Science Science (multidisciplinary) Sympathetic Nervous System - cytology Sympathetic Nervous System - metabolism Transport processes Valosin Containing Protein Yeasts |
| title | Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T06%3A05%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Valosin-containing%20protein,%20VCP,%20is%20a%20ubiquitous%20clathrin-binding%20protein&rft.jtitle=Nature%20(London)&rft.au=Pleasure,%20Irene%20T&rft.date=1993-09-30&rft.volume=365&rft.issue=6445&rft.spage=459&rft.epage=462&rft.pages=459-462&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/365459a0&rft_dat=%3Cproquest_cross%3E4949718%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c488t-e43dbb920202e38bfe8f43d828e45d4dfabe0a6b44c66463a0c6cce869497053%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=204450978&rft_id=info:pmid/8413590&rfr_iscdi=true |