Molecular epidemiology of foot-and-mouth disease virus type O

1 Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, 28049 Cantoblanco and 2 Centro de Investigación en Sanidad Animal, INIA, 28130 Valdeolmos, Madrid, Spain A phylogenetic tree based on the VP1 sequences of type O foot-and-mouth disease virus (FMDV) has been der...

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Bibliographic Details
Published in:Journal of general virology 1993-10, Vol.74 (10), p.2281-2285
Main Authors: Saiz, Juan Carlos, Sobrino, Francisco, Dopazo, Joaquin
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Aphthovirus - genetics
Base Sequence
Biological and medical sciences
Europe - epidemiology
Foot-and-Mouth Disease - epidemiology
foot-and-mouth disease virus
Fundamental and applied biological sciences. Psychology
Genetics
Microbiology
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Viral Proteins - genetics
Virology
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Summary:1 Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, 28049 Cantoblanco and 2 Centro de Investigación en Sanidad Animal, INIA, 28130 Valdeolmos, Madrid, Spain A phylogenetic tree based on the VP1 sequences of type O foot-and-mouth disease virus (FMDV) has been derived. Direct sequencing of PCR products has been used to obtain the VP1 gene sequences of new isolates. The tree exhibits four main lineages that largely correlate with the geographical origin of isolates. The analysis supports a close relationship between European O1 field isolates and vaccine strains, with the exception of O Thalheim Aus/81 and O Wuppertal Ger/82 which were probably of non-European origin. Analysis of nucleotide substitutions indicates that synonymous mutations play a major role in FMDV evolution. Received 15 February 1993; accepted 11 June 1993.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-74-10-2281