Limited diversity of the rearranged T-cell γ gene

The immunoglobulin-related, T-cell specific γ gene is rearranged in a wide variety of murine T lymphocytes. We detected γ-gene transcripts in all cloned cytotoxic T lymphocytes examined but in only 1 of 11 T-helper cell lines or hybridomas. Although in cytotoxic T cells, the rearranged γ gene seems...

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Bibliographic Details
Published in:Nature (London) 1985-01, Vol.313 (6005), p.752-755
Main Authors: Kranz, David M., Saito, Haruo, Heller, Mark, Takagaki, Yohtaroh, Haas, Werner, Eisen, Herman N., Tonegawa, Susumu
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analysis of the immune response. Humoral and cellular immunity
Animals
Base Sequence
Biological and medical sciences
Cell Differentiation
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Genes. Genome
Humanities and Social Sciences
Immunobiology
Mice
Molecular and cellular biology
Molecular genetics
multidisciplinary
Organs and cells involved in the immune response
Receptors, Antigen, T-Cell - genetics
Recombination, Genetic
Science
Science (multidisciplinary)
Spleen - cytology
T-Lymphocytes - cytology
T-Lymphocytes - physiology
T-Lymphocytes, Cytotoxic - physiology
Thymus Gland - cytology
Transcription, Genetic
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Summary:The immunoglobulin-related, T-cell specific γ gene is rearranged in a wide variety of murine T lymphocytes. We detected γ-gene transcripts in all cloned cytotoxic T lymphocytes examined but in only 1 of 11 T-helper cell lines or hybridomas. Although in cytotoxic T cells, the rearranged γ gene seems to have been assembled from the same germ-line variable and joining gene segments, the transcribed gene exhibited distinct sequence diversity near the junction between these segments.
ISSN:0028-0836
1476-4687
DOI:10.1038/313752a0