Accelerated hypertension - patterns of mortality and clinical factors affecting outcome in treated patients

We evaluated the outcome of patients presenting with accelerated hypertension, as part of an audit of the Aberdeen Hypertension Clinic database. Of 3928 patients (2005 male, 1923 female) referred for assessment of hypertension, 128 (77 male, 51 female) presented with accelerated hypertension. The ma...

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Bibliographic Details
Published in:Quarterly journal of medicine 1993-08, Vol.86 (8), p.485-493
Main Authors: WEBSTER, J, PETRIE, J. C, JEFFERS, T. A, LOVELL, H. G
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensive agents
Biological and medical sciences
Blood Pressure
Cardiovascular system
Cause of Death
Female
Humans
Hypertension - mortality
Hypertension - physiopathology
Life Tables
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prognosis
Referral and Consultation
Risk Factors
Scotland - epidemiology
Time Factors
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Summary:We evaluated the outcome of patients presenting with accelerated hypertension, as part of an audit of the Aberdeen Hypertension Clinic database. Of 3928 patients (2005 male, 1923 female) referred for assessment of hypertension, 128 (77 male, 51 female) presented with accelerated hypertension. The main outcome measures were systolic and diastolic pressure, length of time from referral to death or censor date, and cause of death. Accelerated hypertensives had a higher death rate than other hypertensives. Using life-table analysis, age and serum creatinine at referral were sufficient to predict survival. Almost 50% (15/31) of the deceased accelerated hypertensives died of acute myocardial infarction. Mean survival after referral was estimated as 18 years for accelerated hypertensives (mean referral age 52 years) and 21 years for other hypertensives (mean referral age 48 years). Blood pressure fell most during the first year of treatment, and declined steadily thereafter. Systolic blood pressure fell by a mean of 50 mmHg and diastolic pressure by 30 mmHg in the first year, and at about 2 (diastolic) and 1 (systolic) mmHg/year for the next 10 years. Thus although the prognosis for accelerated hypertensives is not quite as good as for other hypertensives, with suitable care they can survive for a considerable period.
ISSN:0033-5622
2058-1130
DOI:10.1093/qjmed/86.8.485