Paraneoplastic glomerulopathy secondary to retroperitoneal sarcoma: A case report

Glomerulopathy is a rare form of paraneoplastic disease. We present the second reported case of paraneoplastic glomerulopathy due to a retroperitoneal sarcoma. The patient presented with generalized edema and nephrotic syndrome. CT scan showed two large retroperitoneal masses. One large retroperiton...

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Bibliographic Details
Published in:Journal of surgical oncology 2010-11, Vol.102 (6), p.704-705
Main Authors: Sherman, Jingjing L., Liu, Eric Y., Ozao‐Choy, Junko, Winston, Jonathan A., Lee, Johnny, Dikman, Steven H., Divino, Celia M.
Format: Article
Language:English
Subjects:
Adult
Female
Humans
minimal change disease
Nephrosis, Lipoid - complications
nephrotic syndrome. Anasarca
paraneoplastic glomerulopathy
Paraneoplastic Syndromes - complications
Retroperitoneal Neoplasms - complications
retroperitoneum sarcoma
Sarcoma - complications
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Summary:Glomerulopathy is a rare form of paraneoplastic disease. We present the second reported case of paraneoplastic glomerulopathy due to a retroperitoneal sarcoma. The patient presented with generalized edema and nephrotic syndrome. CT scan showed two large retroperitoneal masses. One large retroperitoneal mass was resected. Post‐operatively, she developed kidney failure and biopsy showed minimal change disease. With steroid therapy, patient's symptoms went into remission. We hypothesize that minimal change paraneoplastic glomerulopathy developed due to damage from cytokines released from a T‐cell mediated response to the malignancy. J. Surg. Oncol. 2010;102:704–705. © 2010 Wiley‐Liss, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.21689