Increased Plasma Interleukin-1 Activity in Women after Ovulation

The polypeptide interleukin-1 mediates many host responses to infection and inflammation. A method was developed for studying interleukin-1 levels in human plasma from febrile patients. Interleukin-1 activity was also consistently found in plasma samples from women in the luteal phase of their menst...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1985-03, Vol.227 (4691), p.1247-1249
Main Authors: Cannon, Joseph G., Dinarello, Charles A.
Format: Article
Language:English
Subjects:
Animals
Antiserum
Biological and medical sciences
Blood
Blood plasma
Body Temperature
Female
Fever
Fever - physiopathology
Follicular Phase
Fundamental and applied biological sciences. Psychology
Humans
Immunologic research
Immunological research
Infections
Interleukin-1
Interleukin-1 - analysis
Interleukin-1 - physiology
Interleukins
Luteal Phase
Male
Mammalian female genital system
Menstrual cycle
Mice
Morphology. Physiology
Ovulation
Physiological aspects
Protein research
Thymocytes
Vertebrates: reproduction
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Summary:The polypeptide interleukin-1 mediates many host responses to infection and inflammation. A method was developed for studying interleukin-1 levels in human plasma from febrile patients. Interleukin-1 activity was also consistently found in plasma samples from women in the luteal phase of their menstrual cycle. This activity was neutralized by a specific antiserum to human interleukin-1 and was low in plasma from healthy men and preovulatory women. Thus interleukin-1 appears to have a role in normal physiological conditions as well as in disease states.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3871966