P(4-VP) based nanoparticles and composites with dual action as antimicrobial materials

Polymeric 4-VP (p(4-VP)) particles were synthesized in an oil-in-water microemulsion system using various amounts of ethylene glycol dimethacrylate (EGDMA) as crosslinker. The prepared p(4-VP) particles were chemically modified to obtain positively charged particles as polyelectrolytes. Furthermore,...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2010-09, Vol.79 (2), p.460-466
Main Authors: Ozay, Ozgur, Akcali, Alper, Otkun, Müşerref Tatman, Silan, Coskun, Aktas, Nahit, Sahiner, Nurettin
Format: Article
Language:English
Subjects:
Absorption - drug effects
Anti-Infective Agents - pharmacology
Antibacterial material
Bacillus subtilis
Bacteria - drug effects
Emulsions
Escherichia coli
Methacrylates - chemistry
Methacrylates - pharmacology
Microbial Sensitivity Tests
Modified p(4-VP)
Nanocomposites
Nanocomposites - chemistry
Nanocomposites - ultrastructure
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Polymeric nanoparticles
Polymers - pharmacology
Polyvinyls - pharmacology
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus
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Summary:Polymeric 4-VP (p(4-VP)) particles were synthesized in an oil-in-water microemulsion system using various amounts of ethylene glycol dimethacrylate (EGDMA) as crosslinker. The prepared p(4-VP) particles were chemically modified to obtain positively charged particles as polyelectrolytes. Furthermore, these p(4-VP) particles were used for in situ Ag and Cu metal nanoparticle syntheses to provide dual action with an additional advantage as bactericidal particles. The synthesized p(4-VP) particles with positive charges and metal constituents were tested for potential antibacterial action against various bacteria such as Staphylococcus aureus ATCC6538, Pseduomonas aeruginosa ATCC9027, Bacillus subtilis ATCC6633, Escherichia coli ATCC8739. It was found that p(4-VP) particles, especially the positively charged forms had potential as antibacterial materials. The synthesized particle dimensions were characterized with TEM, and DLS measurements. Chemical modification of the particles was confirmed by FT-IR spectroscopy and zeta potential measurements, and the metal nanoparticle contents were determined with thermogravimetric (TGA) studies.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2010.05.013