Morbidity after paediatric cardiac surgery assessed with usage of medicines: a population-based registry study

• Published in: Cardiology in the young 2010-12, Vol.20 (6), p.660-667
• Main Authors: Nieminen, Heta P., Sairanen, Heikki I., Jokinen, Eero V.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anti-Bacterial Agents - therapeutic use; asthma; Asthma - complications; Asthma - drug therapy; Cardiac Surgical Procedures; Cardiovascular Agents - therapeutic use; Cardiovascular Diseases - complications; Cardiovascular Diseases - drug therapy; cardiovascular medication; Child; Chronic Disease - drug therapy; comorbidity; Congenital cardiac defects; epilepsy; Epilepsy - complications; Epilepsy - drug therapy; Follow-Up Studies; Heart Defects, Congenital - complications; Heart Defects, Congenital - surgery; Humans; Mental Disorders - complications; Mental Disorders - drug therapy; Middle Aged; psychiatric diseases; Young Adult
• ISSN: 1047-9511; 1467-1107
• DOI: 10.1017/S1047951110000922

To examine the overall morbidity of patients who underwent surgery for congenital cardiac defect during childhood. A congenital cardiac defect treated with surgery is seldom totally cured. The incidence of residua, sequelae, and comorbidity is quite high. The morbidity has not been thoroughly examined. Medication was used as an indicator of morbidity. Data from the Finnish Research Registry of Paediatric Cardiac Surgery were linked to data from the medication registry of Finland's Social Insurance Institution. This study includes 5116 patients with a mean age of 33.5 (ranged from 14.7 to 64.8) years, who had undergone surgery for congenital cardiac defect between 1953 and 1989. The use of medicines among patients in 2004 was compared with 10232 age- and sex-matched control subjects. The overall use of medicines was frequent; 62% of patients and 53% of controls had purchased at least one prescribed medicine (risk ratio: 1.2, 95% confidence interval: 1.1-1.2). The number of patients using cardiovascular medicines (17%) and anti-thrombotic agents (5%) was higher than that of control subjects (risk ratio: 2.2 and 8.4). In addition, the patients needed medicinal care for epilepsy (3%), asthma (7%), and psychiatric diseases (10%) more often than did controls (risk ratio: 2.2, 1.5, and 1.3, respectively). Patients operated on for congenital cardiac defect had more chronic diseases and used more medicines than did controls.