Health consequences of reproductive aging: a commentary

This commentary discusses the intersection of human ovarian and somatic aging. It argues for re‐contextualizing estrogen's role in and impact on ovarian aging and, more broadly, on women's health, considering in particular the importance of timing, dose, and the broader endocrine milieu. D...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2010-08, Vol.1204 (1), p.163-168
Main Author: Harlow, Siobán D.
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Bias
Correlation
Demand
Female
Health
Human
Humans
Longevity
Longevity - physiology
Marketing
Optimization
ovarian aging
Ovary - physiology
Reproduction - physiology
somatic aging
Time measurements
Women's Health
Womens health
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Summary:This commentary discusses the intersection of human ovarian and somatic aging. It argues for re‐contextualizing estrogen's role in and impact on ovarian aging and, more broadly, on women's health, considering in particular the importance of timing, dose, and the broader endocrine milieu. Distinguishing between current clinical needs and optimizing women's future options, the paper outlines an approach to broadening the research agenda to better understand the role of ovarian aging in supporting the metabolic demands of longevity. Three overarching issues important to consider explicitly as we pursue research on the health correlates of reproductive aging are discussed, including implications of a lifespan approach, population diversity, and selection bias.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2010.05641.x