Alcohol consumption as a risk factor for pneumonia: a systematic review and meta-analysis

The aim of this study was to quantify the association between alcohol consumption and incidence of pneumonia and to examine possible pathways. This was done by a systematic review and meta-analyses on the dose–response relationship between alcohol consumption or alcohol-use disorders and the inciden...

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Bibliographic Details
Published in:Epidemiology and infection 2010-12, Vol.138 (12), p.1789-1795
Main Authors: SAMOKHVALOV, A. V., IRVING, H. M., REHM, J.
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult and adolescent clinical studies
Alcohol
alcohol dependence
Alcohol drinking
Alcohol Drinking - adverse effects
Alcohol related disorders
Alcoholic beverages
Alcoholism
Alcoholism and acute alcohol poisoning
Alcohols
Biological and medical sciences
causality
Chronic obstructive pulmonary disease
Community-Acquired Infections - epidemiology
Datasets
Dose response relationship
Drug dosages
Epidemiology
Estimates
Ethanol
Female
heavy drinking
Humans
Incidence
Male
Medical sciences
Morbidity
Mortality
Pneumonia
Pneumonia - epidemiology
Pneumonia and other respiratory infections
Predisposing factors
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk Factors
Systematic review
Toxicology
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Summary:The aim of this study was to quantify the association between alcohol consumption and incidence of pneumonia and to examine possible pathways. This was done by a systematic review and meta-analyses on the dose–response relationship between alcohol consumption or alcohol-use disorders and the incidence of community-acquired pneumonia (CAP). The relative risk (RR) of CAP increased monotonically with increasing alcohol consumption. Individuals consuming 24, 60, and 120 g of pure alcohol daily demonstrated RRs for incident CAP of 1·12 (95% CI 1·02–1·23), 1·33 (95% CI 1·06–1·67) and 1·76 (95% CI 1·13–2·77), respectively, relative to non-drinkers. Clinically defined alcohol-use disorders were associated with an eightfold increased risk of CAP (RR 8·22, 95% CI 4·85–13·95). In conclusion, alcohol was found to be a risk factor for pneumonia with a clear statistical association, and a monotonic dose–response relationship.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268810000774