Cyanoacrylate tissue adhesive for closing skin wounds: a double blind randomized comparison with sutures

A comparative double blind randomized study was undertaken in the rat, to compare the external cosmetic and the morphologic aspect of skin wounds, treated by the local application of adhesive glue (ethyl-2-cyanoacrylate-Mediglue®) or classical suture technique. Skin incisions were applied and treate...

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Bibliographic Details
Published in:Biomaterials 1993-08, Vol.14 (10), p.737-742
Main Authors: Vanholder, R., Misotten, A., Roels, H., Matton, G.
Format: Article
Language:English
Subjects:
Adhesive
Adhesives
Animals
Biological and medical sciences
cyanoacrylate
Cyanoacrylates
Double-Blind Method
Male
Medical sciences
Random Allocation
Rats
Rats, Wistar
Regression Analysis
Skin - injuries
Skin plastic surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Suture Techniques
wound closure
Wound Healing
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Summary:A comparative double blind randomized study was undertaken in the rat, to compare the external cosmetic and the morphologic aspect of skin wounds, treated by the local application of adhesive glue (ethyl-2-cyanoacrylate-Mediglue®) or classical suture technique. Skin incisions were applied and treated by a plastic surgeon, then photographed or biopsied, and evaluated and scored by independent observers, not aware of the initial treatment. Small (1.5cm) or long (8 cm) incisions were made, on both sides of the back, and treated randomly on one side by glue and on the other side by sutures. Evaluations were performed at 1, 2, 4 and 8 wk. Both small and large wounds scored identically, irrespective of the treatment (overall score 1.5 cm wounds: 8.8 ± 1.4 for glue versos 8.8 ± 1.0 for sutures; 8 cm wounds: 8.3 ± 1.9 versus 8.3 ± 1.5; P = not significant). A morphological study demonstrated no adverse effects for the adhesive treatment, with a minor inflammatory infiltrate. Sutured wounds had a higher tendency to develop abscesses and/or major inflammation. Adhesive-treated wounds scored better than non-treated wounds (8.9 ± 1.3 versus 7.4 ± 3.3, P < 0.01). In conclusion, this controlled comparative study shows no difference in cosmetic aspect between adhesive and suturetreated skin incisions. Morphologically, the glue treatment is not related to any adverse effect or damage to the skin structures.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(93)90037-3