Evidence for two bladder cancer suppressor loci on human chromosome 9

Most carcinomas of the bladder show loss of heterozygosity for markers on human chromosome 9, which suggests that one or more tumor suppressor genes are located on this chromosome. Several observations suggest that such alterations are an important early step in tumorigenesis. We analyzed the patter...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1993-11, Vol.53 (21), p.5093-5095
Main Authors: RUPPERT, J. M, TOKINO, K, SIDRANSKY, D
Format: Article
Language:English
Subjects:
Biological and medical sciences
carcinoma
chromosome 9
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, Pair 9
DNA, Neoplasm - analysis
Genes, Tumor Suppressor
Genetic Markers
Humans
man
Medical sciences
Nephrology. Urinary tract diseases
Polymerase Chain Reaction
Polymorphism, Genetic
tumor suppressor genes
Tumors of the urinary system
urinary bladder
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - surgery
Urinary tract. Prostate gland
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Most carcinomas of the bladder show loss of heterozygosity for markers on human chromosome 9, which suggests that one or more tumor suppressor genes are located on this chromosome. Several observations suggest that such alterations are an important early step in tumorigenesis. We analyzed the pattern of allelic loss in 46 primary carcinomas of the bladder using 19 polymorphic markers from chromosome 9. While most tumors with allelic loss showed loss of heterozygosity for all informative markers that were tested, six tumors demonstrated only partial loss of chromosome 9. Two tumors with partial loss contained deletions that predominantly involved the q arm, as shown by previous studies. The other four tumors contained deletions that predominantly or exclusively involved the p arm, with a common region of loss between D9S161 (9p21) and the telomere. The results show that there is no single common region of loss on chromosome 9 and identify two distinct regions of loss that may contain bladder tumor suppressor loci.
ISSN:0008-5472
1538-7445