Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass

Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined. Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomuc...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1985-03, Vol.5 (2), p.220-223
Main Authors: Serbource‐Goguel/Seta, Nathalie, Borel, Béatrice, Dodeur, Michèle, Scarmato, Pierre, Bourel, Benoit, Feger, Jeanne, Durand, Geneviève
Format: Article
Language:English
Subjects:
Animals
Asialoglycoprotein Receptor
Asialoglycoproteins
Endocytosis
Ileum - surgery
Jejunum - surgery
Liver - cytology
Liver - metabolism
Liver Diseases - blood
Liver Diseases - etiology
Liver Diseases - metabolism
Male
Orosomucoid - analogs & derivatives
Orosomucoid - metabolism
Rats
Rats, Inbred Strains
Receptors, Immunologic - metabolism
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Summary:Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined. Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomucoid by bypassed rat hepatocytes was decreased by about 60%. This was due to a decreased number of total and surface receptors. In most sera, an accumulation of asialoorosomucoid was found. A reduction of protein synthesis or turnover could be considered.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840050211