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Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass
Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined. Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomuc...
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| Published in: | Hepatology (Baltimore, Md.) Md.), 1985-03, Vol.5 (2), p.220-223 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3401-278d36950a5420e7ddaa4f8c9fb897d7b2ad5626925dba453801b423ef76080c3 |
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| cites | cdi_FETCH-LOGICAL-c3401-278d36950a5420e7ddaa4f8c9fb897d7b2ad5626925dba453801b423ef76080c3 |
| container_end_page | 223 |
| container_issue | 2 |
| container_start_page | 220 |
| container_title | Hepatology (Baltimore, Md.) |
| container_volume | 5 |
| creator | Serbource‐Goguel/Seta, Nathalie Borel, Béatrice Dodeur, Michèle Scarmato, Pierre Bourel, Benoit Feger, Jeanne Durand, Geneviève |
| description | Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined.
Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomucoid by bypassed rat hepatocytes was decreased by about 60%. This was due to a decreased number of total and surface receptors. In most sera, an accumulation of asialoorosomucoid was found. A reduction of protein synthesis or turnover could be considered. |
| doi_str_mv | 10.1002/hep.1840050211 |
| format | article |
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Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomucoid by bypassed rat hepatocytes was decreased by about 60%. This was due to a decreased number of total and surface receptors. In most sera, an accumulation of asialoorosomucoid was found. A reduction of protein synthesis or turnover could be considered.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.1840050211</identifier><identifier>PMID: 3979953</identifier><language>eng</language><publisher>Philadelphia, PA: W.B. Saunders</publisher><subject>Animals ; Asialoglycoprotein Receptor ; Asialoglycoproteins ; Endocytosis ; Ileum - surgery ; Jejunum - surgery ; Liver - cytology ; Liver - metabolism ; Liver Diseases - blood ; Liver Diseases - etiology ; Liver Diseases - metabolism ; Male ; Orosomucoid - analogs & derivatives ; Orosomucoid - metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Immunologic - metabolism</subject><ispartof>Hepatology (Baltimore, Md.), 1985-03, Vol.5 (2), p.220-223</ispartof><rights>Copyright © 1985 American Association for the Study of Liver Diseases</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3401-278d36950a5420e7ddaa4f8c9fb897d7b2ad5626925dba453801b423ef76080c3</citedby><cites>FETCH-LOGICAL-c3401-278d36950a5420e7ddaa4f8c9fb897d7b2ad5626925dba453801b423ef76080c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3979953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serbource‐Goguel/Seta, Nathalie</creatorcontrib><creatorcontrib>Borel, Béatrice</creatorcontrib><creatorcontrib>Dodeur, Michèle</creatorcontrib><creatorcontrib>Scarmato, Pierre</creatorcontrib><creatorcontrib>Bourel, Benoit</creatorcontrib><creatorcontrib>Feger, Jeanne</creatorcontrib><creatorcontrib>Durand, Geneviève</creatorcontrib><title>Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined.
Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomucoid by bypassed rat hepatocytes was decreased by about 60%. This was due to a decreased number of total and surface receptors. In most sera, an accumulation of asialoorosomucoid was found. A reduction of protein synthesis or turnover could be considered.</description><subject>Animals</subject><subject>Asialoglycoprotein Receptor</subject><subject>Asialoglycoproteins</subject><subject>Endocytosis</subject><subject>Ileum - surgery</subject><subject>Jejunum - surgery</subject><subject>Liver - cytology</subject><subject>Liver - metabolism</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - metabolism</subject><subject>Male</subject><subject>Orosomucoid - analogs & derivatives</subject><subject>Orosomucoid - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Immunologic - metabolism</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqFkDFPwzAUhC0EKqWwsiF5Ykt5tuM4HlFVKFIlGGBElhM71FUSlzgRyr_HVStgY3rDfXdPdwhdE5gTAHq3sbs5yVMADpSQEzQlnIqEMQ6naApUQCIJk-foIoQtAMiU5hM0YVJIydkUvS9b48ux98EFrFuDC9ca135gX2EdnK6973zwzVB6F8URx3-63ztswFXnG9zpPuAv12_w1m6H1rva6jqSOx3CJTqrdB3s1fHO0NvD8nWxStbPj0-L-3VSshRIQkVuWCY5aJ5SsMIYrdMqL2VV5FIYUVBteEYzSbkpdMpZDqRIKbOVyCCHks3Q7SF31_nPwYZeNS6Utq51a_0QVMRYmnERwfkBLGOr0NlK7TrX6G5UBNR-TxX7qd89o-HmmDwUjTU_-HHAqMuD_hV7j_-kqdXy5U_2N0Qygoc</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Serbource‐Goguel/Seta, Nathalie</creator><creator>Borel, Béatrice</creator><creator>Dodeur, Michèle</creator><creator>Scarmato, Pierre</creator><creator>Bourel, Benoit</creator><creator>Feger, Jeanne</creator><creator>Durand, Geneviève</creator><general>W.B. Saunders</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass</title><author>Serbource‐Goguel/Seta, Nathalie ; Borel, Béatrice ; Dodeur, Michèle ; Scarmato, Pierre ; Bourel, Benoit ; Feger, Jeanne ; Durand, Geneviève</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3401-278d36950a5420e7ddaa4f8c9fb897d7b2ad5626925dba453801b423ef76080c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Asialoglycoprotein Receptor</topic><topic>Asialoglycoproteins</topic><topic>Endocytosis</topic><topic>Ileum - surgery</topic><topic>Jejunum - surgery</topic><topic>Liver - cytology</topic><topic>Liver - metabolism</topic><topic>Liver Diseases - blood</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - metabolism</topic><topic>Male</topic><topic>Orosomucoid - analogs & derivatives</topic><topic>Orosomucoid - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Immunologic - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serbource‐Goguel/Seta, Nathalie</creatorcontrib><creatorcontrib>Borel, Béatrice</creatorcontrib><creatorcontrib>Dodeur, Michèle</creatorcontrib><creatorcontrib>Scarmato, Pierre</creatorcontrib><creatorcontrib>Bourel, Benoit</creatorcontrib><creatorcontrib>Feger, Jeanne</creatorcontrib><creatorcontrib>Durand, Geneviève</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serbource‐Goguel/Seta, Nathalie</au><au>Borel, Béatrice</au><au>Dodeur, Michèle</au><au>Scarmato, Pierre</au><au>Bourel, Benoit</au><au>Feger, Jeanne</au><au>Durand, Geneviève</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>1985-03</date><risdate>1985</risdate><volume>5</volume><issue>2</issue><spage>220</spage><epage>223</epage><pages>220-223</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><abstract>Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined.
Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomucoid by bypassed rat hepatocytes was decreased by about 60%. This was due to a decreased number of total and surface receptors. In most sera, an accumulation of asialoorosomucoid was found. A reduction of protein synthesis or turnover could be considered.</abstract><cop>Philadelphia, PA</cop><pub>W.B. Saunders</pub><pmid>3979953</pmid><doi>10.1002/hep.1840050211</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0270-9139 |
| ispartof | Hepatology (Baltimore, Md.), 1985-03, Vol.5 (2), p.220-223 |
| issn | 0270-9139 1527-3350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76034657 |
| source | Alma/SFX Local Collection |
| subjects | Animals Asialoglycoprotein Receptor Asialoglycoproteins Endocytosis Ileum - surgery Jejunum - surgery Liver - cytology Liver - metabolism Liver Diseases - blood Liver Diseases - etiology Liver Diseases - metabolism Male Orosomucoid - analogs & derivatives Orosomucoid - metabolism Rats Rats, Inbred Strains Receptors, Immunologic - metabolism |
| title | Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass |
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