Ouabain Binding and Na+ Content in Resistance Vessels and Skeletal Muscles of Spontaneously Hypertensive Rats K+-Depleted Rats

The possible role of Na in the development of hypertension in rats was explored in measurements of intracellular Na, Na efflux, and H-ouabain binding sites in resistance vessels and skeletal muscles. In resistance vessels obtained from 13-week-old spontaneously hypertensive rats (SHR) or age-matched...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1985-03, Vol.7 (2), p.277-286
Main Authors: AALKJÆR, CHRISTIAN, KJELDSEN, KELD, NORGAARD, AAGE, CLAUSEN, TORBEN, MULVANY, MICHAEL J
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Arterioles - metabolism
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Experimental diseases
Female
Hypertension - metabolism
Male
Medical sciences
Muscle, Smooth, Vascular - metabolism
Muscles - metabolism
Ouabain - metabolism
Potassium - metabolism
Rats
Rats, Inbred SHR
Sodium - metabolism
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Summary:The possible role of Na in the development of hypertension in rats was explored in measurements of intracellular Na, Na efflux, and H-ouabain binding sites in resistance vessels and skeletal muscles. In resistance vessels obtained from 13-week-old spontaneously hypertensive rats (SHR) or age-matched Wistar-Kyoto rats (WKY), (Na)1, total or ouabain-resistant Na efflux, and the concentration of H-ouabain binding sites showed no significant differences. Soleus muscles obtained from 6-week-old and 13-week-old SHR contained 5 to 11% more H-ouabain binding sites than those of WKY. The small difference in ouabain binding probably was related more to variations in growth rate and strain than to the hypertension. In SHR and WKY the Na and K contents of gastrocnemius muscles were almost identical at 6 and 13 weeks of age. By contrast, in Wistar rats in which the (Na), of skeletal muscle was increased sixfold by K depletion, the systolic blood pressure was decreased by 10%. The K depletion was associated with a 35 to 55% decrease in the concentration of H-ouabain binding sites in both resistance vessels and skeletal muscles. The results provide no support for any simple cause-effect relationships between either elevated (Na)1 or altered concentration of H-ouabain binding sites and hypertension in SHR.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.7.2.277