Loading…
Decreased chloramphenicol clearance in malnourished Ethiopian children
The disposition of chloramphenicol and chloramphenicol monosuccinate has been studied in thirty-four Ethiopian children of varying nutritional status. After a single intravenous dose corresponding to chloramphenicol 25 mg per kg bodyweight, the plasma clearance of chloramphenicol monosuccinate was d...
Saved in:
Published in: | European journal of clinical pharmacology 1993-09, Vol.45 (2), p.181-186 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c311t-e439caf3b6e73eac55f944fa763ee781fbbaa34e36b55ac413f08c230c690c913 |
---|---|
cites | cdi_FETCH-LOGICAL-c311t-e439caf3b6e73eac55f944fa763ee781fbbaa34e36b55ac413f08c230c690c913 |
container_end_page | 186 |
container_issue | 2 |
container_start_page | 181 |
container_title | European journal of clinical pharmacology |
container_volume | 45 |
creator | ASHTON, M BOLME, P ALEMAYEHU, E ERIKSSON, M PAALZOW, L |
description | The disposition of chloramphenicol and chloramphenicol monosuccinate has been studied in thirty-four Ethiopian children of varying nutritional status. After a single intravenous dose corresponding to chloramphenicol 25 mg per kg bodyweight, the plasma clearance of chloramphenicol monosuccinate was decreased only in severely malnourished children with kwashiorkor. Seventeen % of the dose (range 0-51%) was recovered in urine as intact prodrug, indicating incomplete and variable bioavailability of chloramphenicol. Compared to underweight children, on average marasmic and kwashiorkor subjects exhibited a 2- and 3-fold increase, respectively, in the AUC of chloramphenicol. Elevated AUCs could be traced to reduced hepatic clearance of the drug. The unbound fraction both of chloramphenicol and its prodrug were slightly elevated in serum from kwashiorkor subjects. The possibility of using a single point measurement of plasma chloramphenicol as a guide to individualized dosage are discussed. |
doi_str_mv | 10.1007/BF00315503 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76037838</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76037838</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-e439caf3b6e73eac55f944fa763ee781fbbaa34e36b55ac413f08c230c690c913</originalsourceid><addsrcrecordid>eNpFkL9PwzAQhS0EKqWwsCNlQAxIATvnxMkIpQWkSiwwRxf3rBg5P7Cbgf-eVI3KdNK9773hY-xa8AfBuXp8XnMOIk05nLC5kJDEgktxyub7d5wVip-zixC-ORdpwWHGZnmSQC6TOVu_kPaEgbaRrl3nselraq3uXKQdocdWU2TbqEHXdoO3oR7J1a62XW-xHTvWbT21l-zMoAt0Nd0F-1qvPpdv8ebj9X35tIk1CLGLSUKh0UCVkQJCnaamkNKgyoBI5cJUFSJIgqxKU9RSgOG5ToDrrOC6ELBgd4fd3nc_A4Vd2digyTlsqRtCqTIOKod8BO8PoPZdCJ5M2XvboP8tBS_30sp_aSN8M60OVUPbIzpZGvPbKceg0Zm9FRuOGCipihH7Ay4nc50</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76037838</pqid></control><display><type>article</type><title>Decreased chloramphenicol clearance in malnourished Ethiopian children</title><source>Springer Online Journal Archives</source><creator>ASHTON, M ; BOLME, P ; ALEMAYEHU, E ; ERIKSSON, M ; PAALZOW, L</creator><creatorcontrib>ASHTON, M ; BOLME, P ; ALEMAYEHU, E ; ERIKSSON, M ; PAALZOW, L</creatorcontrib><description>The disposition of chloramphenicol and chloramphenicol monosuccinate has been studied in thirty-four Ethiopian children of varying nutritional status. After a single intravenous dose corresponding to chloramphenicol 25 mg per kg bodyweight, the plasma clearance of chloramphenicol monosuccinate was decreased only in severely malnourished children with kwashiorkor. Seventeen % of the dose (range 0-51%) was recovered in urine as intact prodrug, indicating incomplete and variable bioavailability of chloramphenicol. Compared to underweight children, on average marasmic and kwashiorkor subjects exhibited a 2- and 3-fold increase, respectively, in the AUC of chloramphenicol. Elevated AUCs could be traced to reduced hepatic clearance of the drug. The unbound fraction both of chloramphenicol and its prodrug were slightly elevated in serum from kwashiorkor subjects. The possibility of using a single point measurement of plasma chloramphenicol as a guide to individualized dosage are discussed.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00315503</identifier><identifier>PMID: 8223842</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Biological Availability ; Child ; Child, Preschool ; Chloramphenicol - analogs & derivatives ; Chloramphenicol - pharmacokinetics ; Ethiopia ; Female ; Humans ; Infant ; Kwashiorkor - metabolism ; Male ; Medical sciences ; Metabolic Clearance Rate ; Nutrition Disorders - metabolism ; Pharmacology. Drug treatments ; Prodrugs - metabolism ; Prodrugs - pharmacokinetics ; Protein Binding ; Protein-Energy Malnutrition - metabolism</subject><ispartof>European journal of clinical pharmacology, 1993-09, Vol.45 (2), p.181-186</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-e439caf3b6e73eac55f944fa763ee781fbbaa34e36b55ac413f08c230c690c913</citedby><cites>FETCH-LOGICAL-c311t-e439caf3b6e73eac55f944fa763ee781fbbaa34e36b55ac413f08c230c690c913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3747942$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8223842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ASHTON, M</creatorcontrib><creatorcontrib>BOLME, P</creatorcontrib><creatorcontrib>ALEMAYEHU, E</creatorcontrib><creatorcontrib>ERIKSSON, M</creatorcontrib><creatorcontrib>PAALZOW, L</creatorcontrib><title>Decreased chloramphenicol clearance in malnourished Ethiopian children</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The disposition of chloramphenicol and chloramphenicol monosuccinate has been studied in thirty-four Ethiopian children of varying nutritional status. After a single intravenous dose corresponding to chloramphenicol 25 mg per kg bodyweight, the plasma clearance of chloramphenicol monosuccinate was decreased only in severely malnourished children with kwashiorkor. Seventeen % of the dose (range 0-51%) was recovered in urine as intact prodrug, indicating incomplete and variable bioavailability of chloramphenicol. Compared to underweight children, on average marasmic and kwashiorkor subjects exhibited a 2- and 3-fold increase, respectively, in the AUC of chloramphenicol. Elevated AUCs could be traced to reduced hepatic clearance of the drug. The unbound fraction both of chloramphenicol and its prodrug were slightly elevated in serum from kwashiorkor subjects. The possibility of using a single point measurement of plasma chloramphenicol as a guide to individualized dosage are discussed.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chloramphenicol - analogs & derivatives</subject><subject>Chloramphenicol - pharmacokinetics</subject><subject>Ethiopia</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Kwashiorkor - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Nutrition Disorders - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Prodrugs - metabolism</subject><subject>Prodrugs - pharmacokinetics</subject><subject>Protein Binding</subject><subject>Protein-Energy Malnutrition - metabolism</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNpFkL9PwzAQhS0EKqWwsCNlQAxIATvnxMkIpQWkSiwwRxf3rBg5P7Cbgf-eVI3KdNK9773hY-xa8AfBuXp8XnMOIk05nLC5kJDEgktxyub7d5wVip-zixC-ORdpwWHGZnmSQC6TOVu_kPaEgbaRrl3nselraq3uXKQdocdWU2TbqEHXdoO3oR7J1a62XW-xHTvWbT21l-zMoAt0Nd0F-1qvPpdv8ebj9X35tIk1CLGLSUKh0UCVkQJCnaamkNKgyoBI5cJUFSJIgqxKU9RSgOG5ToDrrOC6ELBgd4fd3nc_A4Vd2digyTlsqRtCqTIOKod8BO8PoPZdCJ5M2XvboP8tBS_30sp_aSN8M60OVUPbIzpZGvPbKceg0Zm9FRuOGCipihH7Ay4nc50</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>ASHTON, M</creator><creator>BOLME, P</creator><creator>ALEMAYEHU, E</creator><creator>ERIKSSON, M</creator><creator>PAALZOW, L</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930901</creationdate><title>Decreased chloramphenicol clearance in malnourished Ethiopian children</title><author>ASHTON, M ; BOLME, P ; ALEMAYEHU, E ; ERIKSSON, M ; PAALZOW, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-e439caf3b6e73eac55f944fa763ee781fbbaa34e36b55ac413f08c230c690c913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chloramphenicol - analogs & derivatives</topic><topic>Chloramphenicol - pharmacokinetics</topic><topic>Ethiopia</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Kwashiorkor - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Nutrition Disorders - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Prodrugs - metabolism</topic><topic>Prodrugs - pharmacokinetics</topic><topic>Protein Binding</topic><topic>Protein-Energy Malnutrition - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ASHTON, M</creatorcontrib><creatorcontrib>BOLME, P</creatorcontrib><creatorcontrib>ALEMAYEHU, E</creatorcontrib><creatorcontrib>ERIKSSON, M</creatorcontrib><creatorcontrib>PAALZOW, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ASHTON, M</au><au>BOLME, P</au><au>ALEMAYEHU, E</au><au>ERIKSSON, M</au><au>PAALZOW, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased chloramphenicol clearance in malnourished Ethiopian children</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>45</volume><issue>2</issue><spage>181</spage><epage>186</epage><pages>181-186</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The disposition of chloramphenicol and chloramphenicol monosuccinate has been studied in thirty-four Ethiopian children of varying nutritional status. After a single intravenous dose corresponding to chloramphenicol 25 mg per kg bodyweight, the plasma clearance of chloramphenicol monosuccinate was decreased only in severely malnourished children with kwashiorkor. Seventeen % of the dose (range 0-51%) was recovered in urine as intact prodrug, indicating incomplete and variable bioavailability of chloramphenicol. Compared to underweight children, on average marasmic and kwashiorkor subjects exhibited a 2- and 3-fold increase, respectively, in the AUC of chloramphenicol. Elevated AUCs could be traced to reduced hepatic clearance of the drug. The unbound fraction both of chloramphenicol and its prodrug were slightly elevated in serum from kwashiorkor subjects. The possibility of using a single point measurement of plasma chloramphenicol as a guide to individualized dosage are discussed.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>8223842</pmid><doi>10.1007/BF00315503</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0031-6970 |
ispartof | European journal of clinical pharmacology, 1993-09, Vol.45 (2), p.181-186 |
issn | 0031-6970 1432-1041 |
language | eng |
recordid | cdi_proquest_miscellaneous_76037838 |
source | Springer Online Journal Archives |
subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biological Availability Child Child, Preschool Chloramphenicol - analogs & derivatives Chloramphenicol - pharmacokinetics Ethiopia Female Humans Infant Kwashiorkor - metabolism Male Medical sciences Metabolic Clearance Rate Nutrition Disorders - metabolism Pharmacology. Drug treatments Prodrugs - metabolism Prodrugs - pharmacokinetics Protein Binding Protein-Energy Malnutrition - metabolism |
title | Decreased chloramphenicol clearance in malnourished Ethiopian children |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T10%3A08%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20chloramphenicol%20clearance%20in%20malnourished%20Ethiopian%20children&rft.jtitle=European%20journal%20of%20clinical%20pharmacology&rft.au=ASHTON,%20M&rft.date=1993-09-01&rft.volume=45&rft.issue=2&rft.spage=181&rft.epage=186&rft.pages=181-186&rft.issn=0031-6970&rft.eissn=1432-1041&rft_id=info:doi/10.1007/BF00315503&rft_dat=%3Cproquest_cross%3E76037838%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c311t-e439caf3b6e73eac55f944fa763ee781fbbaa34e36b55ac413f08c230c690c913%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=76037838&rft_id=info:pmid/8223842&rfr_iscdi=true |