Effect of precursors on biosynthesis of monensins A and B

Precursors of monensins (acetate, propionate, butyrate, isobutyrate) affect the total production and the relative proportion of monensins A and B. Addition of propionate into the fermentation medium causes a prevalence of monensin B whereas butyrate and isobutyrate stimulate the production of monens...

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Bibliographic Details
Published in:Folia microbiologica 1985-01, Vol.30 (1), p.30-33
Main Authors: Pospisil, S, Cimburkova, E, Krumphanzl, V, Vanek, Z. (Ceskoslovenska Akademie Ved, Prague (Czechoslovakia). Mikrobiologicky Ustav)
Format: Article
Language:English
Subjects:
Acetates - pharmacology
Acetic Acid
Butyrates - pharmacology
Butyric Acid
Furans - biosynthesis
Isobutyrates
Monensin - biosynthesis
monensin A
monensin B
Propionates - pharmacology
Streptomyces
Streptomyces - metabolism
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Summary:Precursors of monensins (acetate, propionate, butyrate, isobutyrate) affect the total production and the relative proportion of monensins A and B. Addition of propionate into the fermentation medium causes a prevalence of monensin B whereas butyrate and isobutyrate stimulate the production of monensin A and suppress the production of monensin B.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02922494