Defective immune adherence receptors (CR1) on erythrocytes in autoimmune diseases: An association with HLA–Cw3

• Published in: Arthritis and rheumatism 1985-03, Vol.28 (3), p.349-351
• Main Authors: Matsumura, Yukio, Inokuma, Shigeko, Hayakawa, Tetsuo, Kisaki, Tomonari
• Format: Article
• Language: English
• Subjects: Autoimmune Diseases - genetics; Autoimmune Diseases - immunology; Autoimmune Diseases - pathology; Biological and medical sciences; complement component C3b; General aspects; histocompatibility antigen HLA; HLA Antigens - analysis; HLA-C Antigens; Humans; Immunopathology; Lupus Erythematosus, Systemic - immunology; man; Medical sciences; Pedigree; receptors; Receptors, Complement - genetics; Receptors, Complement - physiology; Receptors, Complement 3b; systemic lupus erythematosus
• ISSN: 0004-3591; 1529-0131
• DOI: 10.1002/art.1780280318

A possible role of erythrocyte immune adherence receptor (C3b receptor, CR1) in removal of circulating immune complexes has been postulated. It has been reported that defective CR1 on erythrocytes was observed in the majority of the patients with systemic lupus erythematosus (SLE) but in only 5% of normal subjects. The defect was suspected to be genetically determined because it was not affected by disease activity or the amount of circulating immune complexes, but stayed unchanged during the course of the disease even after years in remission induced by steroid therapy. The authors investigated a correlation between CR1 abnormality and the major histocompatibility antigens, HLA-A, B, C, and DR, and the authors noticed in a preliminary study that most patients with SLE who had defective CR1 also had HLA-Cw3, although the frequency of HLA-Cw3 among a Japanese population has been reported to be 46.5%. This study provides evidence for the association of defective CR1 with HLA-Cw3 tested in 73 subjects: 38 patients with autoimmune diseases and 35 of their consanguineous relatives.