Lung cancer, race, and a CYP1A1 genetic polymorphism

The assessment of human cancer risk using molecular epidemiological techniques involves determining the relative contributions of inherited and acquired genetic predispositions, in the context of environmental exposures. Recently described genetic polymorphisms for CYP1A1, a gene involved in the met...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1993-09, Vol.2 (5), p.481
Main Authors: Shields, P G, Caporaso, N E, Falk, R T, Sugimura, H, Trivers, G E, Trump, B F, Hoover, R N, Weston, A, Harris, C C
Format: Article
Language:English
Subjects:
Asthma - genetics
Black or African American
Black People - genetics
Blotting, Southern
Case-Control Studies
Cytochrome P-450 Enzyme System - genetics
DNA, Neoplasm - analysis
DNA, Neoplasm - genetics
Gene Frequency
Genotype
Heterozygote
Homozygote
Humans
Lung Diseases, Obstructive - genetics
Lung Neoplasms - genetics
Neoplasms - genetics
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Risk Factors
Smoking - genetics
White People - genetics
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Summary:The assessment of human cancer risk using molecular epidemiological techniques involves determining the relative contributions of inherited and acquired genetic predispositions, in the context of environmental exposures. Recently described genetic polymorphisms for CYP1A1, a gene involved in the metabolic activation of polycyclic aromatic hydrocarbons, have been associated with lung cancer risk in a Japanese population. We report herein findings from a United States case-control study of lung cancer (56 cases; 48 controls). The polymerase chain reaction followed by an Msp1 restriction enzyme digestion was used to analyze constitutive DNA but no association between the restriction fragment length polymorphism and lung cancer risk was found (odds ratio, 0.7; 95% confidence interval, = 0.3-1.6). Analysis of genotype by cumulative smoking status did not reveal an elevated risk among lesser or greater smokers. The presence of the CYP1A1 Msp1 site-present allele, which was previously found to be associated with Japanese lung cancer risk, was statistically increased in African compared to Caucasian Americans (odds ratio, 2.9; 95% confidence interval, 1.2-2.7). When stratified by race, however, no association between case status and the polymorphism was observed, but the small number of study subjects within each racial group limited the statistical power. Larger studies are required to evaluate the risk of the CYP1A1 Msp1 polymorphism in African Americans.
ISSN:1055-9965
1538-7755