Immunologic Parameters 2 Years after High-Titer Measles Immunization in Peruvian Children

Immunization with high-titer measles vaccines has been associated with excess mortality in children 2-4 years after vaccination. In this study, immunologic parameters in 64 Peruvian children who had been immunized an average of 27 months earlier with high-titer vaccines were compared with parameters...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1993-11, Vol.168 (5), p.1097-1104
Main Authors: Elena León, Maria, Ward, Brian, Kanashiro, Rosa, Hernández, Herminio, Berry, Susan, Vaisberg, Abraham, Escamilla, Joel, Campos, Miguel, Belloma, Sicilia, Azabache, Verónica, Halsey, Neal A.
Format: Article
Language:English
Subjects:
Blood
Cell Division
Child, Preschool
Developing Countries
Dose-Response Relationship, Drug
Follow-Up Studies
Humans
Hypersensitivity, Delayed - etiology
Immunization
Immunology
Infant
Infections
Leukocyte Count
Lymphocyte Activation
Lymphocytes
Major Articles
Measles
Measles - epidemiology
Measles - immunology
Measles - prevention & control
Measles Vaccine - administration & dosage
Measles Vaccine - adverse effects
Measles Vaccine - immunology
Measles vaccines
measles virus
Mortality
Peru - epidemiology
Sex Characteristics
T tests
T-Lymphocyte Subsets
Vaccination
Vaccination - mortality
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Immunization with high-titer measles vaccines has been associated with excess mortality in children 2-4 years after vaccination. In this study, immunologic parameters in 64 Peruvian children who had been immunized an average of 27 months earlier with high-titer vaccines were compared with parameters in 76 recipients of low-titer vaccines. Delayed-type hypersensitivity, lymphocyte phenotype distributions by flow cytometry, and lymphoproliferation after phytohemagglutinin (PHA) stimulation were assessed. High-titer recipients had smaller indurations to tetanus, diphtheria, and Proteus (P < .05) antigens, decreased PHA stimulation (P = .04), and a lower percentage of CD4⁺ lymphocytes (P = .04) than low-titer recipients. After adjustment for sex, concurrent illnesses, and other variables in regression analyses, high-titer recipients had a lower percentage of CD4⁺ lymphocytes (P = .025) and decreased lymphocyte proliferation to PHA {P = .058). These results may provide a clue to the pathogenesis of delayed excess mortality after high-titer measles vaccination in some developing countries.
ISSN:0022-1899