BIOLOGICAL PROPERTIES OF AUREOBASIDIN A, A CYCLIC DEPSIPEPTIDE ANTIFUNGAL ANTIBIOTIC

Aureobasidin A (AbA) is a novel cyclic depsipeptide antifungal antibiotic. The antifungal activity of AbA was studied in vitro and in vivo in comparison with clinically effective antifungal agents, amphotericin B and fluconazole. AbA was highly active in vitro against many pathogenic fungi, includin...

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Published in:Journal of antibiotics 1993/09/25, Vol.46(9), pp.1414-1420
Main Authors: TAKESAKO, KAZUTOH, KURODA, HIROYUKI, INOUE, TOSHIAKI, HARUNA, FUMIYO, YOSHIKAWA, YOSHIE, KATO, IKUNOSHIN, UCHIDA, KATSUHISA, HIRATANI, TAMIO, YAMAGUCHI, HIDEYO
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Biological and medical sciences
Candidiasis - drug therapy
Depsipeptides
Female
Kidney - microbiology
Medical sciences
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
Molecular Sequence Data
Peptides, Cyclic - chemistry
Peptides, Cyclic - pharmacology
Peptides, Cyclic - therapeutic use
Pharmacology. Drug treatments
Protein Conformation
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Summary:Aureobasidin A (AbA) is a novel cyclic depsipeptide antifungal antibiotic. The antifungal activity of AbA was studied in vitro and in vivo in comparison with clinically effective antifungal agents, amphotericin B and fluconazole. AbA was highly active in vitro against many pathogenic fungi, including Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis and Histoplasma capsulatum. The activity was superior to amphotericin B in most cases. AbA exhibited fungicidal action toward growing cultures of C. albicans. It was highly tolerated by mice and showed good efficacy in the treatment of murine systemic candidiasis when given orally or subcutaneously. AbA's fungicidal action in mice with candidiasis was more effective than fluconazole and amphotericin B.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1414