Cytological localization of adenosine kinase, nucleoside phosphorylase-1, and esterase-10 genes on mouse chromosome 14

We have determined the regional locations on mouse chromosome 14 of the genes for mouse adenosine kinase (ADK), nucleoside phosphorylase-1 (NP-1), and esterase-10 (ES-10) by analysis of rearranged mouse chromosomes in gamma-irradiated Chinese hamster X mouse hybrid cell lines. Irradiated clones were...

Full description

Saved in:
Bibliographic Details
Published in:Somatic cell and molecular genetics 1985-03, Vol.11 (2), p.157-165
Main Authors: SAMUELSON, L. C, FARBER, R. A
Format: Article
Language:English
Subjects:
Adenosine Kinase - genetics
Animals
Biological and medical sciences
Carboxylesterase
Carboxylic Ester Hydrolases - genetics
Cell Fusion
Cell Line
Chromosome Aberrations
Chromosome Mapping
Chromosomes - radiation effects
Cricetinae
Cytogenetics
Embryo, Mammalian
Female
Fibroblasts
Fundamental and applied biological sciences. Psychology
Gamma Rays
Genetics of eukaryotes. Biological and molecular evolution
Hybrid Cells - radiation effects
Hybrid Cells - ultrastructure
Mice
Ovary
Pentosyltransferases - genetics
Phosphotransferases - genetics
Purine-Nucleoside Phosphorylase - genetics
Vertebrata
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have determined the regional locations on mouse chromosome 14 of the genes for mouse adenosine kinase (ADK), nucleoside phosphorylase-1 (NP-1), and esterase-10 (ES-10) by analysis of rearranged mouse chromosomes in gamma-irradiated Chinese hamster X mouse hybrid cell lines. Irradiated clones were screened for expression of the murine forms of these enzymes; segregant clones that expressed only one or two of the three markers were karyotyped. The patterns of enzyme expression in these segregants were correlated with the presence of rearranged chromosomes. The Adk gene was localized to bands A2 to B, Np-1 to bands B to C1, and Es-10 to bands D2 to E2.
ISSN:0740-7750
1572-9931
DOI:10.1007/BF01534704