Medullary respiratory-related neurons with axonal connections to rostral pons and their function in termination of inspiration

In urethane-anaesthetized, paralyzed and artificially ventilated rabbits, medullary respiration-related neurons (RRU) were classified according to the phase relation of their burst discharge to phrenic nerve activity. Phase-bound inspiratory (I) or expiratory (E) neurons were discriminated from phas...

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Bibliographic Details
Published in:Pflügers Archiv 1985, Vol.403 (1), p.58-65
Main Authors: SCHMID, K, BO:HMER, G, FALLERT, M
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Axons - physiology
Biological and medical sciences
Electric Stimulation
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Medulla Oblongata - cytology
Medulla Oblongata - physiology
Medulla Oblongata - ultrastructure
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Neural Pathways - physiology
Neurons - physiology
Neurons, Afferent - physiology
Other techniques and industries
Pons - physiology
Rabbits
Respiration
Time Factors
Vertebrates: nervous system and sense organs
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Summary:In urethane-anaesthetized, paralyzed and artificially ventilated rabbits, medullary respiration-related neurons (RRU) were classified according to the phase relation of their burst discharge to phrenic nerve activity. Phase-bound inspiratory (I) or expiratory (E) neurons were discriminated from phase-spanning expiratory-inspiratory (EI) or inspiratory-expiratory (IE) units. Mechanisms of termination of inspiration by electrical stimulation of rostral pontine nuclei (Nc. parabrachialis medialis; Lc. coeruleus) were examined firstly to demonstrate whether RRU receive descending excitatory and inhibitory afferents as well as ascending efferents and secondly to analyse the time course of the neuronal pathways involved. Of 120 RRU, 38 neurons were demonstrated to receive pontine afferents. About 33% of all E neurons became orthodromically excited during rostral pons stimulation whereas 18.2% of all I cells became orthodromically inhibited. Some RRU were shown to project up to the rostral pons. 50% of these were of the phase-spanning IE type. The onset of inspiratory inhibition induced by rostral pons stimulation occurred 3.4 ms after the onset of single electrical pulse stimulation. Based on these results a neuronal model for a pontine mechanism terminating inspiration is proposed.
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00583283