Regulation of Transmural Myocardial Blood Flow

A major problem in understanding how myocardial blood flow is regulated is the common occurrence of subendocardial ischemia in many diseases, with or without coronary arterial disease. Two commonly held explanatory hypotheses were that high systolic intramyocardial pressures prevented flow to deep b...

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Bibliographic Details
Published in:Journal of biomechanical engineering 1985-02, Vol.107 (1), p.2-9
Main Authors: Hoffman, J. I. E, Baer, R. W, Hanley, F. L, Messina, L. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomechanical Phenomena
Biomechanics. Biorheology
Blood Pressure
Coronary Circulation
Diastole
Fundamental and applied biological sciences. Psychology
Humans
Models, Cardiovascular
Regional Blood Flow
Systole
Tissues, organs and organisms biophysics
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Summary:A major problem in understanding how myocardial blood flow is regulated is the common occurrence of subendocardial ischemia in many diseases, with or without coronary arterial disease. Two commonly held explanatory hypotheses were that high systolic intramyocardial pressures prevented flow to deep but not superficial muscle, or that in diastole tissue pressures were highest subendocardially. Neither hypothesis is tenable today, and the likeliest hypothesis is that retrograde systolic flow from the deeper muscle produces a longer time constant for diastolic flow in deep than in superficial muscle.
ISSN:0148-0731
1528-8951
DOI:10.1115/1.3138516