Genetic Variations of the Hepatitis B Virus and Their Clinical Relevance

A current topic of hepatitis B virus (HBV) study is genetic variations of the HBV DNA. The discovery of precore-defective mutations at the time of hepatitis B e antigen (HBeAg) to anti-HBe sero conversion (HBe-SC) and in fulminant hepatitis B has opened a new field of HBV research. The advent of a p...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1993, Vol.37(6), pp.425-439
Main Author: Uchida, Toshikazu
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Core mutant
DNA, Viral - genetics
Epitopes - genetics
Fulminant hepatitis
Genes, Viral - genetics
Genetic Variation
Genome variation
HBcAg
HBeAg
Hepatitis B - genetics
Hepatitis B - immunology
Hepatitis B e Antigens - physiology
hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatitis B virus - physiology
Human viral diseases
Humans
Infectious diseases
Medical sciences
Mutation
Precore mutation
Seroconversion
Viral diseases
Viral hepatitis
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Summary:A current topic of hepatitis B virus (HBV) study is genetic variations of the HBV DNA. The discovery of precore-defective mutations at the time of hepatitis B e antigen (HBeAg) to anti-HBe sero conversion (HBe-SC) and in fulminant hepatitis B has opened a new field of HBV research. The advent of a powerful technique of molecular biology, i.e., polymerase chain reaction (PCR), facilitates the cloning and sequencing of the HBV DNA. In fact, most of the HBV DNA sequence data published in recent years have used the PCR method. The HBV DNAs were directly after PCR amplification as described elsewhere. The data have now been submitted or accepted for publication. Based on these data the author will describe the genetic variations of precore/core genes and their clinical implications and attempt to obtain answers to the above questions. This review will add new information to the previous reviews. The nonsynonymous nucleotide substitution changing one amino acid alone will be described from the author's data. Synonymous substitutions were found roughly two to three times more frequent than nonsynonymous substitutions in the precore/core genes in the author's investigation. Genetic variations of the HBV DNA outside the precore/core gene will be summarized from the data in the references.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1993.tb03233.x