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Genetic Variations of the Hepatitis B Virus and Their Clinical Relevance
A current topic of hepatitis B virus (HBV) study is genetic variations of the HBV DNA. The discovery of precore-defective mutations at the time of hepatitis B e antigen (HBeAg) to anti-HBe sero conversion (HBe-SC) and in fulminant hepatitis B has opened a new field of HBV research. The advent of a p...
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| Published in: | MICROBIOLOGY and IMMUNOLOGY 1993, Vol.37(6), pp.425-439 |
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| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c6123-6d670f86128b7a495e761ca2570334f4adcc92aebb4963a53cbfca0eef0c62cc3 |
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| cites | cdi_FETCH-LOGICAL-c6123-6d670f86128b7a495e761ca2570334f4adcc92aebb4963a53cbfca0eef0c62cc3 |
| container_end_page | 439 |
| container_issue | 6 |
| container_start_page | 425 |
| container_title | MICROBIOLOGY and IMMUNOLOGY |
| container_volume | 37 |
| creator | Uchida, Toshikazu |
| description | A current topic of hepatitis B virus (HBV) study is genetic variations of the HBV DNA. The discovery of precore-defective mutations at the time of hepatitis B e antigen (HBeAg) to anti-HBe sero conversion (HBe-SC) and in fulminant hepatitis B has opened a new field of HBV research. The advent of a powerful technique of molecular biology, i.e., polymerase chain reaction (PCR), facilitates the cloning and sequencing of the HBV DNA. In fact, most of the HBV DNA sequence data published in recent years have used the PCR method. The HBV DNAs were directly after PCR amplification as described elsewhere. The data have now been submitted or accepted for publication. Based on these data the author will describe the genetic variations of precore/core genes and their clinical implications and attempt to obtain answers to the above questions. This review will add new information to the previous reviews. The nonsynonymous nucleotide substitution changing one amino acid alone will be described from the author's data. Synonymous substitutions were found roughly two to three times more frequent than nonsynonymous substitutions in the precore/core genes in the author's investigation. Genetic variations of the HBV DNA outside the precore/core gene will be summarized from the data in the references. |
| doi_str_mv | 10.1111/j.1348-0421.1993.tb03233.x |
| format | article |
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The discovery of precore-defective mutations at the time of hepatitis B e antigen (HBeAg) to anti-HBe sero conversion (HBe-SC) and in fulminant hepatitis B has opened a new field of HBV research. The advent of a powerful technique of molecular biology, i.e., polymerase chain reaction (PCR), facilitates the cloning and sequencing of the HBV DNA. In fact, most of the HBV DNA sequence data published in recent years have used the PCR method. The HBV DNAs were directly after PCR amplification as described elsewhere. The data have now been submitted or accepted for publication. Based on these data the author will describe the genetic variations of precore/core genes and their clinical implications and attempt to obtain answers to the above questions. This review will add new information to the previous reviews. The nonsynonymous nucleotide substitution changing one amino acid alone will be described from the author's data. Synonymous substitutions were found roughly two to three times more frequent than nonsynonymous substitutions in the precore/core genes in the author's investigation. 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The discovery of precore-defective mutations at the time of hepatitis B e antigen (HBeAg) to anti-HBe sero conversion (HBe-SC) and in fulminant hepatitis B has opened a new field of HBV research. The advent of a powerful technique of molecular biology, i.e., polymerase chain reaction (PCR), facilitates the cloning and sequencing of the HBV DNA. In fact, most of the HBV DNA sequence data published in recent years have used the PCR method. The HBV DNAs were directly after PCR amplification as described elsewhere. The data have now been submitted or accepted for publication. Based on these data the author will describe the genetic variations of precore/core genes and their clinical implications and attempt to obtain answers to the above questions. This review will add new information to the previous reviews. The nonsynonymous nucleotide substitution changing one amino acid alone will be described from the author's data. Synonymous substitutions were found roughly two to three times more frequent than nonsynonymous substitutions in the precore/core genes in the author's investigation. Genetic variations of the HBV DNA outside the precore/core gene will be summarized from the data in the references.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Core mutant</subject><subject>DNA, Viral - genetics</subject><subject>Epitopes - genetics</subject><subject>Fulminant hepatitis</subject><subject>Genes, Viral - genetics</subject><subject>Genetic Variation</subject><subject>Genome variation</subject><subject>HBcAg</subject><subject>HBeAg</subject><subject>Hepatitis B - genetics</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B e Antigens - physiology</subject><subject>hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B virus - physiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Precore mutation</subject><subject>Seroconversion</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqVkV9v0zAUxS0EGmXwEZAihHhL8L_YCU-wbjSTNpCmUR6vHPeGuqRJsVPovj0uqSLeEH6wr3zOPbZ-l5BXjGYsrrebjAlZpFRylrGyFNlQU8GFyA6PyGySHpMZFUWe5orSp-RZCBtKueaFPCNnWpWSynJGqgV2ODibLI13ZnB9F5K-SYY1JhXu4sXgQnKRLJ3fh8R0q-R-jc4n89Z1zpo2ucMWf5rO4nPypDFtwBen85x8-Xh1P6_Sm8-L6_mHm9QqxkWqVkrTpoh1UWsjyxy1YtbwXFMhZCPNytqSG6xrWSphcmHrxhqK2FCruLXinLwZc3e-_7HHMMDWBYttazrs9wG0ojnXqvinkSnFIx4Wje9Go_V9CB4b2Hm3Nf4BGIUjb9jAESococKRN5x4wyE2vzy9sq-3uJpaT4Cj_vqkmxB5NT6ycmGyyUJLqWW0vR9tv1yLD__xAbi9vv1TxoirMWITBvMNpwzj43hbhG2cnmOl1iA0qHGTPJ90uzYesIs56ZjjwoCHv2K-g9JC5_D10wKWF_NqcVddwqX4DeYoxA8</recordid><startdate>19930101</startdate><enddate>19930101</enddate><creator>Uchida, Toshikazu</creator><general>Blackwell Publishing Ltd</general><general>Center For Academic Publications Japan</general><general>Center for Academic Publications Japan</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19930101</creationdate><title>Genetic Variations of the Hepatitis B Virus and Their Clinical Relevance</title><author>Uchida, Toshikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6123-6d670f86128b7a495e761ca2570334f4adcc92aebb4963a53cbfca0eef0c62cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Core mutant</topic><topic>DNA, Viral - genetics</topic><topic>Epitopes - genetics</topic><topic>Fulminant hepatitis</topic><topic>Genes, Viral - genetics</topic><topic>Genetic Variation</topic><topic>Genome variation</topic><topic>HBcAg</topic><topic>HBeAg</topic><topic>Hepatitis B - genetics</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B e Antigens - physiology</topic><topic>hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B virus - physiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Precore mutation</topic><topic>Seroconversion</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uchida, Toshikazu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>MICROBIOLOGY and IMMUNOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uchida, Toshikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Variations of the Hepatitis B Virus and Their Clinical Relevance</atitle><jtitle>MICROBIOLOGY and IMMUNOLOGY</jtitle><addtitle>Microbiology and Immunology</addtitle><date>1993-01-01</date><risdate>1993</risdate><volume>37</volume><issue>6</issue><spage>425</spage><epage>439</epage><pages>425-439</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><coden>MIIMDV</coden><abstract>A current topic of hepatitis B virus (HBV) study is genetic variations of the HBV DNA. The discovery of precore-defective mutations at the time of hepatitis B e antigen (HBeAg) to anti-HBe sero conversion (HBe-SC) and in fulminant hepatitis B has opened a new field of HBV research. The advent of a powerful technique of molecular biology, i.e., polymerase chain reaction (PCR), facilitates the cloning and sequencing of the HBV DNA. In fact, most of the HBV DNA sequence data published in recent years have used the PCR method. The HBV DNAs were directly after PCR amplification as described elsewhere. The data have now been submitted or accepted for publication. Based on these data the author will describe the genetic variations of precore/core genes and their clinical implications and attempt to obtain answers to the above questions. This review will add new information to the previous reviews. The nonsynonymous nucleotide substitution changing one amino acid alone will be described from the author's data. Synonymous substitutions were found roughly two to three times more frequent than nonsynonymous substitutions in the precore/core genes in the author's investigation. Genetic variations of the HBV DNA outside the precore/core gene will be summarized from the data in the references.</abstract><cop>Tokyo</cop><pub>Blackwell Publishing Ltd</pub><pmid>7694049</pmid><doi>10.1111/j.1348-0421.1993.tb03233.x</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-5600 |
| ispartof | MICROBIOLOGY and IMMUNOLOGY, 1993, Vol.37(6), pp.425-439 |
| issn | 0385-5600 1348-0421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76052768 |
| source | Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Core mutant DNA, Viral - genetics Epitopes - genetics Fulminant hepatitis Genes, Viral - genetics Genetic Variation Genome variation HBcAg HBeAg Hepatitis B - genetics Hepatitis B - immunology Hepatitis B e Antigens - physiology hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B virus - physiology Human viral diseases Humans Infectious diseases Medical sciences Mutation Precore mutation Seroconversion Viral diseases Viral hepatitis |
| title | Genetic Variations of the Hepatitis B Virus and Their Clinical Relevance |
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