Cytotoxicity of Hymenocallis expansa Alkaloids

From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1993-08, Vol.56 (8), p.1423-1425
Main Authors: Antoun, Mikhail D, Mendoza, Nilda T, Ríos, Yolanda R, Proctor, George R, Wickramaratne, D. B. Mahinda, Pezzuto, John M, Kinghorn, A. Douglas
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
ALCALOIDE
ALCALOIDES
ALKALOIDS
Alkaloids - isolation & purification
Alkaloids - pharmacology
Amaryllidaceae Alkaloids
Animals
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
BULBE
BULBO
BULBS
Cell Line
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
FEUILLE
FITOTOXICIDAD
HOJAS
Humans
HYMENOCALLIS
LEAVES
MEDICAMENT CYTOSTATIQUE
Mice
Phenanthridines
PHYTOTOXICITE
PHYTOTOXICITY
PLANT EXTRACTS
Plants, Medicinal - chemistry
PORTO RICO
PUERTO RICO
Tumor Cells, Cultured - drug effects
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Description
Summary:From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50098a030