Study of hepatic binding protein activity in jejuno-ileal by-passed rat hepatocytes

The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno-ileal by-passed rat hepatocytes. In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. More...

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Bibliographic Details
Published in:FEBS letters 1985-04, Vol.183 (2), p.232-234
Main Authors: Serbource-Goguel, Nathalie, Dodeur, Michèle, Borel, Béatrice, Feger, Jeanne, Agneray, Jean, Durand, Geneviève
Format: Article
Language:English
Subjects:
Animals
Asialoglycoprotein Receptor
Asialoglycoproteins
Asialoorosomucoid
Biological and medical sciences
Carrier Proteins - metabolism
Disease Models, Animal
Gastroenterology. Liver. Pancreas. Abdomen
Hepatic binding protein
Ileum - physiology
Isolated hepatocyte
Jejuno-ileal by-pass
Jejunum - physiology
Kinetics
Liver - metabolism
Liver Cirrhosis - metabolism
Liver damage
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Orosomucoid - analogs & derivatives
Orosomucoid - metabolism
Other diseases. Semiology
Rats
Rats, Inbred Strains
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Summary:The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno-ileal by-passed rat hepatocytes. In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. Moreover, the rate constant of internalization was the same in the two groups of rats. These data suggest that the process of asialoorosomucoid internalization is not altered in by-passed hepatocytes and that the decrease of maximal velocity is only due to a decrease of total uptake receptor number.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(85)80783-3