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Study of hepatic binding protein activity in jejuno-ileal by-passed rat hepatocytes
The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno-ileal by-passed rat hepatocytes. In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. More...
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| Published in: | FEBS letters 1985-04, Vol.183 (2), p.232-234 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3643-6730cef9fad001f945766302aac71d7d75a49d8f9bb0cf6be2e99f471fc768d43 |
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| cites | cdi_FETCH-LOGICAL-c3643-6730cef9fad001f945766302aac71d7d75a49d8f9bb0cf6be2e99f471fc768d43 |
| container_end_page | 234 |
| container_issue | 2 |
| container_start_page | 232 |
| container_title | FEBS letters |
| container_volume | 183 |
| creator | Serbource-Goguel, Nathalie Dodeur, Michèle Borel, Béatrice Feger, Jeanne Agneray, Jean Durand, Geneviève |
| description | The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno-ileal by-passed rat hepatocytes. In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. Moreover, the rate constant of internalization was the same in the two groups of rats. These data suggest that the process of asialoorosomucoid internalization is not altered in by-passed hepatocytes and that the decrease of maximal velocity is only due to a decrease of total uptake receptor number. |
| doi_str_mv | 10.1016/0014-5793(85)80783-3 |
| format | article |
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In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. Moreover, the rate constant of internalization was the same in the two groups of rats. These data suggest that the process of asialoorosomucoid internalization is not altered in by-passed hepatocytes and that the decrease of maximal velocity is only due to a decrease of total uptake receptor number.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(85)80783-3</identifier><identifier>PMID: 3987890</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Asialoglycoprotein Receptor ; Asialoglycoproteins ; Asialoorosomucoid ; Biological and medical sciences ; Carrier Proteins - metabolism ; Disease Models, Animal ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatic binding protein ; Ileum - physiology ; Isolated hepatocyte ; Jejuno-ileal by-pass ; Jejunum - physiology ; Kinetics ; Liver - metabolism ; Liver Cirrhosis - metabolism ; Liver damage ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Orosomucoid - analogs & derivatives ; Orosomucoid - metabolism ; Other diseases. Semiology ; Rats ; Rats, Inbred Strains</subject><ispartof>FEBS letters, 1985-04, Vol.183 (2), p.232-234</ispartof><rights>1985</rights><rights>FEBS Letters 183 (1985) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3643-6730cef9fad001f945766302aac71d7d75a49d8f9bb0cf6be2e99f471fc768d43</citedby><cites>FETCH-LOGICAL-c3643-6730cef9fad001f945766302aac71d7d75a49d8f9bb0cf6be2e99f471fc768d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579385807833$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8576260$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3987890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serbource-Goguel, Nathalie</creatorcontrib><creatorcontrib>Dodeur, Michèle</creatorcontrib><creatorcontrib>Borel, Béatrice</creatorcontrib><creatorcontrib>Feger, Jeanne</creatorcontrib><creatorcontrib>Agneray, Jean</creatorcontrib><creatorcontrib>Durand, Geneviève</creatorcontrib><title>Study of hepatic binding protein activity in jejuno-ileal by-passed rat hepatocytes</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno-ileal by-passed rat hepatocytes. In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. Moreover, the rate constant of internalization was the same in the two groups of rats. These data suggest that the process of asialoorosomucoid internalization is not altered in by-passed hepatocytes and that the decrease of maximal velocity is only due to a decrease of total uptake receptor number.</description><subject>Animals</subject><subject>Asialoglycoprotein Receptor</subject><subject>Asialoglycoproteins</subject><subject>Asialoorosomucoid</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - metabolism</subject><subject>Disease Models, Animal</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatic binding protein</subject><subject>Ileum - physiology</subject><subject>Isolated hepatocyte</subject><subject>Jejuno-ileal by-pass</subject><subject>Jejunum - physiology</subject><subject>Kinetics</subject><subject>Liver - metabolism</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver damage</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Orosomucoid - analogs & derivatives</subject><subject>Orosomucoid - metabolism</subject><subject>Other diseases. Semiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqNkE1P3DAQhi3UCra0_wCkHCrUHlLsdeKPCxIgtq2ExIH2bDn2GLzKJlvbWZR_j0NWe6w4eTzzzjszD0JnBP8gmLBLjElV1lzSb6L-LjAXtKRHaEEEz0HFxAe0OEhO0KcY1zj_BZHH6JhKwYXEC_T4mAY7Fr0rnmGrkzdF4zvru6diG_oEviu0SX7n01jkeA3roetL34Jui2YstzpGsEXQaW7vzZggfkYfnW4jfNm_p-jv6u7P7a_y_uHn79vr-9JQVtGScYoNOOm0zXs5WdWcMYqXWhtOLLe81pW0wsmmwcaxBpYgpas4cYYzYSt6ii5m37zqvwFiUhsfDbSt7qAfouIM17xmMgurWWhCH2MAp7bBb3QYFcFqYqkmUGoCpUSt3lgqmtvO9_5DswF7aNrDy_Wv-7qORrcu6M74eJCJfM-STbLVLHvJ3MZ3jVaru5vlVJjyon7LTvtczUaQoe48BBWNh86A9QFMUrb3_z_oFWZ6o9E</recordid><startdate>19850422</startdate><enddate>19850422</enddate><creator>Serbource-Goguel, Nathalie</creator><creator>Dodeur, Michèle</creator><creator>Borel, Béatrice</creator><creator>Feger, Jeanne</creator><creator>Agneray, Jean</creator><creator>Durand, Geneviève</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850422</creationdate><title>Study of hepatic binding protein activity in jejuno-ileal by-passed rat hepatocytes</title><author>Serbource-Goguel, Nathalie ; Dodeur, Michèle ; Borel, Béatrice ; Feger, Jeanne ; Agneray, Jean ; Durand, Geneviève</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3643-6730cef9fad001f945766302aac71d7d75a49d8f9bb0cf6be2e99f471fc768d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Asialoglycoprotein Receptor</topic><topic>Asialoglycoproteins</topic><topic>Asialoorosomucoid</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - metabolism</topic><topic>Disease Models, Animal</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatic binding protein</topic><topic>Ileum - physiology</topic><topic>Isolated hepatocyte</topic><topic>Jejuno-ileal by-pass</topic><topic>Jejunum - physiology</topic><topic>Kinetics</topic><topic>Liver - metabolism</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver damage</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Orosomucoid - analogs & derivatives</topic><topic>Orosomucoid - metabolism</topic><topic>Other diseases. Semiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serbource-Goguel, Nathalie</creatorcontrib><creatorcontrib>Dodeur, Michèle</creatorcontrib><creatorcontrib>Borel, Béatrice</creatorcontrib><creatorcontrib>Feger, Jeanne</creatorcontrib><creatorcontrib>Agneray, Jean</creatorcontrib><creatorcontrib>Durand, Geneviève</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serbource-Goguel, Nathalie</au><au>Dodeur, Michèle</au><au>Borel, Béatrice</au><au>Feger, Jeanne</au><au>Agneray, Jean</au><au>Durand, Geneviève</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of hepatic binding protein activity in jejuno-ileal by-passed rat hepatocytes</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1985-04-22</date><risdate>1985</risdate><volume>183</volume><issue>2</issue><spage>232</spage><epage>234</epage><pages>232-234</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno-ileal by-passed rat hepatocytes. In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. Moreover, the rate constant of internalization was the same in the two groups of rats. These data suggest that the process of asialoorosomucoid internalization is not altered in by-passed hepatocytes and that the decrease of maximal velocity is only due to a decrease of total uptake receptor number.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3987890</pmid><doi>10.1016/0014-5793(85)80783-3</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1985-04, Vol.183 (2), p.232-234 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | ScienceDirect |
| subjects | Animals Asialoglycoprotein Receptor Asialoglycoproteins Asialoorosomucoid Biological and medical sciences Carrier Proteins - metabolism Disease Models, Animal Gastroenterology. Liver. Pancreas. Abdomen Hepatic binding protein Ileum - physiology Isolated hepatocyte Jejuno-ileal by-pass Jejunum - physiology Kinetics Liver - metabolism Liver Cirrhosis - metabolism Liver damage Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Orosomucoid - analogs & derivatives Orosomucoid - metabolism Other diseases. Semiology Rats Rats, Inbred Strains |
| title | Study of hepatic binding protein activity in jejuno-ileal by-passed rat hepatocytes |
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